Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9NVV4 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293A cell | - |
Homo sapiens | - |
General Information | Comment | Organism |
---|---|---|
physiological function | processing of the common precursor releases an incomplete tRNATyr lacking the 3'-adenosine which has to be added before addition of the CCA end and subsequent aminoacylation. Mitochondrial poly(A) polymerase mtPAP is responsible for this A addition. Complete repair can be reconstituted in vitro with three enzymes: mtPAP frequently adds more than one A to the 3'-end of the truncated tRNA, and either the mitochondrial deadenylase PDE12 or the endonuclease RNase Z trims the oligo(A) tail to a single A before CCA addition | Homo sapiens |