Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.7.19 extracted from

  • Thuresson, A.; Kirsebom, L.A.; Virtanen, A.
    Inhibition of poly(A) polymerase by aminoglycosides (2007), Biochimie, 89, 1221-1227.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
PAPgamma(1-683C), a C-terminally truncated version of full length human PAPgamma with the same catalytic efficiency is expressed in Escherichia coli Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
5-epi-sisomycin pH-dependent inhibition, non-competitive inhibitor for ATP Homo sapiens
hygromycin B pH-dependent inhibition Homo sapiens
kanamycin A pH-dependent inhibition Homo sapiens
kanamycin B pH-dependent inhibition Homo sapiens
lividomycin A pH-dependent inhibition Homo sapiens
additional information not inhibited by neamine Homo sapiens
neomycin B an increase in pH releases the neomycin B inhibitory effect on PAPgamma Homo sapiens
paromomycin pH-dependent inhibition Homo sapiens
ribostamycin pH-dependent inhibition Homo sapiens
sisomicin pH-dependent inhibition, non-competitive inhibitor for ATP Homo sapiens
tobramycin pH-dependent inhibition Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ Mg2+ ions can release the inhibition of PAPgamma by aminoglycosides Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme is responsible for the synthesis of the poly(A) tail at the 3'-end of eukaryotic mRNA ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + RNA
-
Homo sapiens diphosphate + RNA(A)n
-
?
additional information the enzyme is responsible for the synthesis of the poly(A) tail at the 3'-end of eukaryotic mRNA Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
PAPgamma
-
Homo sapiens
poly(A) polymerase gamma
-
Homo sapiens