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Literature summary for 2.7.6.1 extracted from

  • Hove-Jensen, B.
    Heterooligomeric phosphoribosyl diphosphate synthase of Saccharomyces cerevisiae: combinatorial expression of the five PRS genes in Escherichia coli (2004), J. Biol. Chem., 279, 40345-40350.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression of the five PRS genes individually in an Escherichia coli PRPP-less strain shows that a single PRS gene product has no PRPP synthase activity. Certain pairwise combinations of subunits produce an active enzyme, yeast PRPP synthase requires at least three different subunits to be stable in vitro Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
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Subunits

Subunits Comment Organism
More expression of the five PRS genes individually in an Escherichia coli PRPP-less strain shows that a single PRS gene product has no PRPP synthase activity. Certain pairwise combinations of subunits produce an active enzyme, yeast PRPP synthase requires at least three different subunits to be stable in vitro Saccharomyces cerevisiae