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Literature summary for 2.7.6.1 extracted from

  • Eriksen, T.A.; Kadziola, A.; Bentsen, A.K.; Harlow, K.W.; Larsen, S.
    Structural basis for the function of Bacillus subtilis phosphoribosyl-pyrophosphate synthetase (2000), Nat. Struct. Biol., 7, 303-308.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
sitting drop vapor diffusion Bacillus subtilis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + D-ribose 5-phosphate Bacillus subtilis the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan AMP + 5-phospho-alpha-D-ribose 1-diphosphate
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r

Organism

Organism UniProt Comment Textmining
Bacillus subtilis
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + D-ribose 5-phosphate
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Bacillus subtilis AMP + 5-phospho-alpha-D-ribose 1-diphosphate
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r
ATP + D-ribose 5-phosphate the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan Bacillus subtilis AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
r

Subunits

Subunits Comment Organism
More the functional form of the enzyme is a homohexamer Bacillus subtilis