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Literature summary for 2.7.3.2 extracted from

  • Boeck, C.R.; Carbonera, L.S.; Milioli, M.E.; Constantino, L.C.; Garcez, M.L.; Rezin, G.T.; Scaini, G.; Streck, E.L.
    Mitochondrial respiratory chain and creatine kinase activities following trauma brain injury in brain of mice preconditioned with N-methyl-D-aspartate (2013), Mol. Cell. Biochem., 384, 129-137.
    View publication on PubMed
Search for more literature for 2.7.3.2

Inhibitors

Inhibitors Comment Organism Structure
4-hydroxymercuribenzoic acid complete inhibition at 0.01 mM Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Mus musculus 5739
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + creatine Mus musculus
-
 ADP + phosphocreatine
-
 r
ATP + creatine Mus musculus CF-1
-
 ADP + phosphocreatine
-
 r

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Mus musculus CF-1
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-
cerebellum
-
 Mus musculus
-
cerebral cortex
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + creatine
-
 Mus musculus ADP + phosphocreatine
-
 r
ATP + creatine
-
 Mus musculus CF-1 ADP + phosphocreatine
-
 r

Synonyms

Synonyms Comment Organism
adenosine-5'-triphosphate: creatine phosphotransferase
-
 Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at, reverse reaction direction Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at, reverse reaction direction Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus

General Information

General Information Comment Organism
malfunction 24 h after trauma brain injury (TBI) of mice preconditioned with N-methyl-D-aspartate, creatine kinase activity is augmented in the cerebral cortex. Eventhough N-methyl-D-aspartate preconditioning and TBI have similar effects on the enzyme activity, each manages its response via opposite mechanisms because the protective effects of preconditioning are unambiguous Mus musculus
physiological function creatine kinase catalyzes the reversible transfer of the phosphoryl group from phosphocreatine to ADP, regenerating ATP, and it is a major enzyme of higher eukaryotes that manages high, fluctuating energy demands to maintain cellular energy homeostasis and guarantee stable, locally buffered ATP/ADP ratios Mus musculus