Literature summary for 2.7.3.2 extracted from

Di-Pietro, P.B.; Dias, M.L.; Scaini, G.; Burigo, M.; Constantino, L.; Machado, R.A.; Dal-Pizzol, F.; Streck, E.L.
Inhibition of brain creatine kinase activity after renal ischemia is attenuated by N-acetylcysteine and deferoxamine administration (2008), Neurosci. Lett., 434, 139-143.

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Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	Wistar	-
Rattus norvegicus Wistar	-	Wistar	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	measurement of creatine kinase activity (hippocampus, striatum, cerebellum, cerebral cortex and prefrontal cortex) in brain if rats are submitted to renal ischemia and the effect of administration of antioxidants (N-acetylcysteine, N-acetylcysteine and deferoxamine, deferoxamine) on this enzyme. Creatine kinase activity is not altered in cerebellum and striatum of rats. Creatine kinase activity is inhibited in prefrontal cortex and hippocampus of rats 12 h after renal ischemia. The treatment with antioxidants prevents such effect. In cerebral cortex creatine kinase activity is inhibited 6 and 12 h after renal ischemia. Only N-acetylcysteine or N-acetylcysteine plus deferoxamine are able to prevent the inhibition on the enzyme. Although it is difficult to extrapolate the findings to the human condition, the inhibition of brain creatine kinase activity after renal failure may be associated to neuronal loss and may be involved in the pathogenesis of uremic encephalopathy	Rattus norvegicus	-
cerebellum	creatine kinase activity is not altered if rats are submitted to renal ischemia	Rattus norvegicus	-
cerebral cortex	in cerebral cortex creatine kinase activity is inhibited 6 and 12 h after renal ischemia. Only N-acetylcysteine or N-acetylcysteine plus deferoxamine are able to prevent the inhibition on the enzyme	Rattus norvegicus	-
corpus striatum	creatine kinase activity is not altered if rats are submitted to renal ischemia	Rattus norvegicus	-
hippocampus	creatine kinase activity is inhibited in prefrontal cortex and hippocampus of rats 12 h after renal ischemia. The treatment with antioxidants prevents such effect	Rattus norvegicus	-
prefrontal cortex	creatine kinase activity is inhibited in prefrontal cortex and hippocampus of rats 12 h after renal ischemia. The treatment with antioxidants prevents such effect	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ADP + phosphocreatine	-	Rattus norvegicus	ATP + creatine	-	?
ADP + phosphocreatine	-	Rattus norvegicus Wistar	ATP + creatine	-	?

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Release 2023.1 (January 2023)