Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Homo sapiens | 5737 | - |
cytosol | HaCaT cells express low levels of cytoplasmic creatine kinase (BB-CK) and high levels of mitochondrial creatine kinase (uMiCK). HeLa-S3 cells express high levels of cytoplasmic creatine kinase (BB-CK) and low levels of mitochondrial creatine kinase (uMiCK) | Homo sapiens | 5829 | - |
mitochondrion | mitochondrial isoform plays the most crucial role in maintaining cell viability by stabilizing contact sites between inner and outer mitochondrial membranse and maintaining local metabolic channeling | Homo sapiens | 5739 | - |
mitochondrion | HaCaT cells express low levels of cytoplasmic creatine kinase (BB-CK) and high levels of mitochondrial creatine kinase (uMiCK). HeLa-S3 cells express high levels of cytoplasmic creatine kinase (BB-CK) and low levels of mitochondrial creatine kinase (uMiCK). The mitochondrial CK isoform plays the most crucial role in maintaining cell viability by stabilizing contact sites between inner and outer mitochondrial membranes and maintaining local metabolite channeling, thus avoiding transition pore opening which eventually results in activation of caspase cell-death pathways | Homo sapiens | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Homo sapiens | P06732 | - |
- |
Homo sapiens | P12277 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HaCaT cell | expresses low levels of cytoplasmic, high levels of mitochondrial creatine kinase. Targeting the dominating isoform by its siRNA has strong effect on overall enzyme activity. Inhibition of mitochondrial isoform causes a strong decline in cell viability and cell proliferation and also substantial alteration of mitochondrial morphology as well as mitochondrial membrane topology | Homo sapiens | - |
HaCaT cell | HaCaT cells express low levels of cytoplasmic creatine kinase (BB-CK) and high levels of mitochondrial creatine kinase (uMiCK). HeLa-S3 cells express high levels of cytoplasmic creatine kinase (BB-CK) and low levels of mitochondrial creatine kinase (uMiCK) | Homo sapiens | - |
HeLa-S3 cell | expresses high levels of cytoplasmic, low levels of mitochondrial creatine kinase. Targeting the dominating isoform by its siRNA has strong effect on overall enzyme activity. Inhibition of mitochondrial isoform causes a strong decline in cell viability and cell proliferation and also substantial alteration of mitochondrial morphology as well as mitochondrial membrane topology | Homo sapiens | - |
HeLa-S3 cell | HaCaT cells express low levels of cytoplasmic creatine kinase (BB-CK) and high levels of mitochondrial creatine kinase (uMiCK). HeLa-S3 cells express high levels of cytoplasmic creatine kinase (BB-CK) and low levels of mitochondrial creatine kinase (uMiCK) | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
BB-CK | - |
Homo sapiens |
uMiCK | - |
Homo sapiens |