Literature summary for 2.7.3.2 extracted from

Assis, L.C.; Scaini, G.; Di-Pietro, P.B.; Castro, A.A.; Comim, C.M.; Streck, E.L.; Quevedo, J.
Effect of antipsychotics on creatine kinase activity in rat brain (2007), Basic Clin. Pharmacol. Toxicol., 101, 315-319.

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Activating Compound

Activating Compound	Comment	Organism	Structure
aripiprazole	activation of enzyme in striatum and cerebral cortex after chronic administration at 10 or 20 mg/kg. No effect on enzyme in hippocampus, cerebellum and prefrontal cortex	Rattus norvegicus
olanzapine	activation of enzyme in striatum after chronic administration at 10 mg/kg	Rattus norvegicus

Application

Application	Comment	Organism
medicine	study on the effect of antipsychotics haloperidol, clozapine, olanzapine or aripiprazole chronic administration on creatine kinase in rat brain	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
clozapine	inhibition of enzyme in cerebellum and prefrontal cortex after chronic administration	Rattus norvegicus
additional information	haloperidol, no effect on enzyme. Aripiprazole, no effect on enzyme in hippocampus, cerebellum and prefrontal cortex	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Rattus norvegicus	-

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Release 2023.1 (January 2023)