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Literature summary for 2.7.2.3 extracted from

  • Wang, J.; Ying, G.; Wang, J.; Jung, Y.; Lu, J.; Zhu, J.; Pienta, K.J.; Taichman, R.S.
    Characterization of phosphoglycerate kinase-1 expression of stromal cells derived from tumor microenvironment in prostate cancer progression (2010), Cancer Res., 70, 471-480.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.2.3

Cloned(Commentary)

Cloned (Comment) Organism
normal or cancer-associated fibroblasts infected with the PGK1 or CXCL12 expressing vector Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
PC-3 cell
-
 Homo sapiens
-
prostate normal or cancer-associated fibroblasts Homo sapiens
-

Synonyms

Synonyms Comment Organism
PGK1
-
 Homo sapiens
phosphoglycerate kinase-1
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens reduced CXCL12 expression inhibits PGK1 expression by cancer-associated fibroblasts down
Homo sapiens PGK1 expression is upregulated in cancer-associated fibroblasts versus normal fibroblasts derived from the prostate peripheral zone. Overexpression of CXCL12 in normal fibroblasts and cancer-associated fibroblasts enhances secretion of PGK1 compared with controls up

General Information

General Information Comment Organism
physiological function PGK1 helps support the interactions between cancer and its microenvironment. A direct and facilitating relationship between CXCL12 and PGK1 levels in the tumor stroma, overexpression of PGK1 increases expression of CXCL12 compared with controls, whereas reducing PGK1 expression decreases expression of CXCL12 levels by cancer-associated fibroblasts. Coimplantation of PGK1-overexpressing fibroblasts with prostate tumor cells promote tumor cell growth in vivo. PGK1 expression in normal fibroblasts stimulates PCalpha proliferation and invasion. Expression of PGK1 and CXCL12 by normal fibroblasts contributes to expression of cancer-associated fibroblast phenotype. Reduced CXCR4 levels in normal fibroblasts that overexpress PGK1 Homo sapiens