Literature summary for 2.7.2.3 extracted from

Osvath, S.; Herenyi, L.; Zavodszky, P.; Fidy, J.; Koehler, G.
Hierarchic finite level energy landscape model: to describe the refolding kinetics of phosphoglycerate kinase (2006), J. Biol. Chem., 281, 24375-24380.

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Application

Application	Comment	Organism
additional information	hierarchic finite level landscape model that quantitatively describes the refolding of yeast phosphoglycerate kinase from 1 ms to 15 min. Early steps of the folding process happen in the upper region of the landscape, where the surface has a hierarchic structure. This leads to stretched kinetics in the early phase of the folding. The lower region of the energy landscape is dominated by a trap that reflects the accumulation of molten globule intermediate state. From this intermediate, the protein can reach the global energy minimum corresponding to the native state through a cross-barrier folding step	Saccharomyces cerevisiae

Protein Variants

Protein Variants	Comment	Organism
P204H	refolding kinetics differ from that of the wild-type	Saccharomyces cerevisiae

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Saccharomyces cerevisiae

Storage Stability

Storage Stability	Organism
-80°C, 50 mM phosphate buffer, pH 6.2	Saccharomyces cerevisiae

Synonyms

Synonyms	Comment	Organism
PGK	-	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)