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Literature summary for 2.7.2.3 extracted from

  • Lay, A.J.; Jiang, X.M.; Kisker, O.; Flynn, E.; Underwood, A.; Condron, R.; Hogg, P.J.
    Phosphoglycerate kinase acts in tumor angiogenesis as a disulfide reductase (2000), Nature, 408, 869-873.
    View publication on PubMed
Search for more literature for 2.7.2.3

Cloned(Commentary)

Cloned (Comment) Organism
DNA sequence determination and expression in Escherichia coli BL21(DE3) Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens enzyme acts as a disulfide reductase, e.g. plasmin reductase, in tumour angiogenesis ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant enzyme from Escherichia coli Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
AsPC-1 cell pancreatic carcinoma cell line, low amount of enzyme compared to HT-1080 cells Homo sapiens
-
BT-20 cell breast carcinoma cell line, reduced amount of enzyme compared to HT-1080 cells Homo sapiens
-
BxPC-3 cell pancreatic carcinoma cell line, low amount of enzyme compared to HT-1080 cells Homo sapiens
-
HS-766T cell pancreatic carcinoma cell line, the same amount of enzyme compared to HT-1080 cells Homo sapiens
-
HS-766T cell pancreatic carcinoma cell line, reduced amount of enzyme compared to HT-1080 cells Homo sapiens
-
HT-1080 cell
-
 Homo sapiens
-
Lim1215 cell colon carcinoma cell line, nearly the same amount of enzyme compared to HT-1080 cells Homo sapiens
-
Lim1863 cell colon carcinoma cell line, increased amount of enzyme compared to HT-1080 cells Homo sapiens
-
Lim2412 cell colon carcinoma cell line, increased amount of enzyme compared to HT-1080 cells Homo sapiens
-
MCF-7 cell breast carcinoma cell line, the same amount of enzyme compared to HT-1080 cells Homo sapiens
-
MDA-MB-231 cell breast carcinoma cell line, low amount of enzyme compared to HT-1080 cells Homo sapiens
-
SU.86.86 cell pancreatic carcinoma cell line, very high amount of enzyme compared to HT-1080 cells Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 3-phospho-D-glycerate
-
 Homo sapiens ADP + 1,3-diphosphoglycerate
-
 r
additional information enzyme acts as a disulfide reductase, e.g. plasmin reductase, in tumour angiogenesis Homo sapiens ?
-
 ?

Cofactor

Cofactor Comment Organism Structure
ADP
-
 Homo sapiens
ATP required as phosphate donor Homo sapiens