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Literature summary for 2.7.2.3 extracted from

  • Li, Y.K.; Byers, L.D.
    Phosphonate inhibitors of glyceraldehyde-3-phosphate dehydrogenase and phosphoglycerate kinase (1993), Biochim. Biophys. Acta, 1164, 17-21.
    View publication on PubMed
Search for more literature for 2.7.2.3

Inhibitors

Inhibitors Comment Organism Structure
1,4-Bisphosphonobutane
-
 Saccharomyces cerevisiae
1,5-Bisphosphonopentane
-
 Saccharomyces cerevisiae
2-Oxo-1,4-bisphosphonobutane
-
 Saccharomyces cerevisiae
2-Oxo-1,5-bisphosphonopentane
-
 Saccharomyces cerevisiae
4-Phosphonobutyronitrile
-
 Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 3-phospho-D-glycerate
-
 Saccharomyces cerevisiae ADP + 1,3-diphosphoglycerate
-
 r

Cofactor

Cofactor Comment Organism Structure
ADP
-
 Saccharomyces cerevisiae
ATP required as phosphate donor Saccharomyces cerevisiae

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.084
-
 2-Oxo-1,4-bisphosphonobutane pH 8.5, 27°C Saccharomyces cerevisiae
0.2
-
 2-Oxo-1,5-bisphosphonopentane pH 8.5, 27°C Saccharomyces cerevisiae
0.56
-
 1,4-Bisphosphonobutane pH 8.5, 27°C Saccharomyces cerevisiae
1.19
-
 1,5-Bisphosphonopentane pH 8.5, 27°C Saccharomyces cerevisiae
3.5
-
 4-Phosphonobutyronitrile pH 8.5, 27°C Saccharomyces cerevisiae