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Literature summary for 2.7.2.11 extracted from

  • Stefl, M.; Vasakova, L.
    Allosteric regulation of proline-inhibitable glutamate kinase from winter-wheat leaves by L-proline, adenosine diphosphate and low temperature (1982), Collect. Czech. Chem. Commun., 47, 360-369.
No PubMed abstract available

Activating Compound

Activating Compound Comment Organism Structure
L-Pro at low temperatures the inhibition switches over into allosteric activation and the biosynthesis of proline is started Triticum aestivum

Inhibitors

Inhibitors Comment Organism Structure
L-Pro IC50: 0.08 mM, at room temperature. At low temperatures the inhibition switches over into allosteric activation and the biosynthesis of proline is started Triticum aestivum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-glutamate Triticum aestivum enzyme GK 1 is the first enzyme of the proline biosynthetic pathway ADP + L-glutamate 5-phosphate
-
?

Organism

Organism UniProt Comment Textmining
Triticum aestivum
-
cv. Mironovska 808
-

Source Tissue

Source Tissue Comment Organism Textmining
leaf
-
Triticum aestivum
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-glutamate
-
Triticum aestivum ADP + L-glutamate 5-phosphate
-
?
ATP + L-glutamate enzyme GK 1 is the first enzyme of the proline biosynthetic pathway Triticum aestivum ADP + L-glutamate 5-phosphate
-
?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.08
-
IC50: 0.08 mM, at room temperature. At low temperatures the inhibition switches over into allosteric activation and the biosynthesis of proline is started Triticum aestivum L-Pro