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Literature summary for 2.7.12.2 extracted from

  • Wang, L.; Chen, C.; Feng, S.; Lei, P.; Tian, J.
    Mitogen-activated protein kinase kinase 3 induces cell cycle arrest via p38 activation mediated Bmi-1 downregulation in hepatocellular carcinoma (2016), Mol. Med. Rep., 13, 243-248.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Homo sapiens P46734
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Source Tissue

Source Tissue Comment Organism Textmining
hepatocellular carcinoma cell
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Homo sapiens
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Synonyms

Synonyms Comment Organism
mitogen-activated protein kinase kinase 3
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Homo sapiens
MKK3
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Homo sapiens

General Information

General Information Comment Organism
physiological function mitogen-activated protein kinase kinase 3, MKK3, overexpression induces cell cycle arrest via p38 activation mediated Bmi-1 downregulation in hepatocellular carcinoma. MKK3 as a tumor suppressor. MKK3 overexpression suppresses HepG2 and PLC-PRF-5 cell proliferation and induces cell cycle arrest in the two cell lines. In addition, MKK3 overexpression upregulates the cyclin-dependent kinase inhibitors, p16 INK4A and p15 INK4B in hepatocellular carcinoma cells. Their negative regulator, Bim?1, is downregulated following MKK3 overexpression. MKK3 activates p38 in hepatocellular carcinoma cells and SB203580, a p38 inhibitor, reverses the tumor suppressive effect of MKK3 Homo sapiens