Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P46734 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hepatocellular carcinoma cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
mitogen-activated protein kinase kinase 3 | - |
Homo sapiens |
MKK3 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | mitogen-activated protein kinase kinase 3, MKK3, overexpression induces cell cycle arrest via p38 activation mediated Bmi-1 downregulation in hepatocellular carcinoma. MKK3 as a tumor suppressor. MKK3 overexpression suppresses HepG2 and PLC-PRF-5 cell proliferation and induces cell cycle arrest in the two cell lines. In addition, MKK3 overexpression upregulates the cyclin-dependent kinase inhibitors, p16 INK4A and p15 INK4B in hepatocellular carcinoma cells. Their negative regulator, Bim?1, is downregulated following MKK3 overexpression. MKK3 activates p38 in hepatocellular carcinoma cells and SB203580, a p38 inhibitor, reverses the tumor suppressive effect of MKK3 | Homo sapiens |