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Literature summary for 2.7.12.2 extracted from

  • Feinstein, T.N.; Linstedt, A.D.
    Mitogen-activated protein kinase kinase 1-dependent Golgi unlinking occurs in G2 phase and promotes the G2/M cell cycle transition (2007), Mol. Biol. Cell, 18, 594-604.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
doxycycline induces expression of HA-MEK1 Homo sapiens

Application

Application Comment Organism
additional information MEK1 plays an in vivo role in Golgi reorganization, which regulates cell cycle progression, MEK signaling promotes G2/M cell cycle transition by unlinking the Golgi, that involves, at least in part, phosphorylation of the putative Golgi structural protein GRASP55 Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
HA-MEK1 cloned into pRevTRE, HA-tagged MEK1 expressed in HeLa cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
siRNA MEK1/2-specific inhibitor, delays, but does not block the passage of synchronized HeLa cells into M phase Homo sapiens
U0126 MEK1/2-specific inhibitor, delays, but does not block the passage of synchronized HeLa cells into M phase Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Synonyms

Synonyms Comment Organism
MEK1
-
Homo sapiens
MEK2
-
Homo sapiens
mitogen-activated protein kinase kinase 1
-
Homo sapiens