Literature summary for 2.7.12.2 extracted from

Xia, D.; Srinivas, H.; Ahn, Y.H.; Sethi, G.; Sheng, X.; Yung, W.K.; Xia, Q.; Chiao, P.J.; Kim, H.; Brown, P.H.; Wistuba, I.I.; Aggarwal, B.B.; Kurie, J.M.
Mitogen-activated protein kinase kinase-4 promotes cell survival by decreasing PTEN expression through an NF kappa B-dependent pathway (2007), J. Biol. Chem., 282, 3507-3519.

Search for more literature for 2.7.12.2

Application

Application	Comment	Organism
additional information	MKK4 promotes the survival of MEF cells by decreasing the expression of phosphatase and tensin homologue deleted from chromosome 10 PTEN. MKK4 inhibits PTEN transcription by activating NFkappaB, a transcriptional suppressor of PTEN. MKK4 is required for nuclear translocation of RelA/p65 and processing of the NFkappaB2 precursor p100 into the mature form p52. MKK4 promotes cell survival by activating phosphatidylinositol 3-kinase through an NFkappaB/PTEN-dependent pathway	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
additional information	MKK4-null MEF cells, are highly susceptible to apoptosis by LY294002, paclitaxel, or serum starvation. MKK4 loss increases PTEN expression and inhibits PI3K-dependent signaling but reveals persistent AKT phosphorylation in serum-starved MKK4-null cells	Mus musculus

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	treatment with LY294002, paclitaxel, or serum starvation does not induce apoptosis of wild-type MEF cells	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
MEF cell	-	Mus musculus	-
additional information	NSCLC cell lines H1299, H226B, H226Br, H332, H358, H460, A549, H596, and Calu-6	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
mitogen-activated protein kinase kinase-4	-	Mus musculus
MKK4/SEK1	-	Mus musculus

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Release 2023.1 (January 2023)