Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | ERK and MEK are activated by phosphorylation, ERK is induced by formalin | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | expression of the neuron-specific dominant negative mitogen activated protein kinase kinase in mutant mice leads to impaired inflammatory pain and thermal hyperalgesia | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
U0126 | MEK inhibitor | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + ERK | Mus musculus | phosphorylation by MEK activates ERK, which plays a role in pain induction modulating the A-type currents of potassium channels in neurons, ERK plays a central role in nocireceptive sensitization in the spinal cord | ADP + phosphorylated ERK | - |
? | |
additional information | Mus musculus | the enzyme is involved in the mitogen-activated protein kinase signaling pathway, which is involved in e.g. formalin-induced inflammatory pain and thermal hyperalgesia, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | ERK and MEK are activated by phosphorylation | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
neuron | - |
Mus musculus | - |
spinal cord | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + ERK | phosphorylation by MEK activates ERK, which plays a role in pain induction modulating the A-type currents of potassium channels in neurons, ERK plays a central role in nocireceptive sensitization in the spinal cord | Mus musculus | ADP + phosphorylated ERK | - |
? | |
ATP + ERK | ERK phosphorylation by MEK | Mus musculus | ADP + phosphorylated ERK | - |
? | |
additional information | the enzyme is involved in the mitogen-activated protein kinase signaling pathway, which is involved in e.g. formalin-induced inflammatory pain and thermal hyperalgesia, overview | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ERK | - |
Mus musculus |
extracellular signal-regulated kinase | - |
Mus musculus |
MEK | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus |