Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | MEK and ERK are activated by phosphorylation | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Berberine | suppresses MEK/ERK-dependent Egr-1 signaling pathway and inhibits vascular smooth muscle cell regrowth after mechanical injury in vitro | Rattus norvegicus | |
U0126 | specific MEK inhibitor | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Rattus norvegicus | the enzyme is involved in the mitogen-activated protein kinase signaling pathway, which is involved in e.g. activation of Egr-1 and subsequently of c-Fos and cyclin D1 after mechanic injury for induction/regulation of regrowth of smooth vascular cells, vascular smooth muscle cell proliferation plays an important role in pathogenesis of atherosclerosis and post-angioplasty restenosis, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
Sprague-Dawley rats | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | MEK and ERK are activated by phosphorylation | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
vascular smooth muscle cell | aortic, cell culture | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme is involved in the mitogen-activated protein kinase signaling pathway, which is involved in e.g. activation of Egr-1 and subsequently of c-Fos and cyclin D1 after mechanic injury for induction/regulation of regrowth of smooth vascular cells, vascular smooth muscle cell proliferation plays an important role in pathogenesis of atherosclerosis and post-angioplasty restenosis, overview | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ERK | - |
Rattus norvegicus |
extracellular-signal-regulated kinase | - |
Rattus norvegicus |
MEK1 | - |
Rattus norvegicus |
MEK2 | - |
Rattus norvegicus |
mitogen-activated protein kinase kinase 1 | - |
Rattus norvegicus |
mitogen-activated protein kinase kinase 2 | - |
Rattus norvegicus |