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Literature summary for 2.7.12.2 extracted from

  • Sugiura, R.; Toda, T.; Dhut, S.; Shuntoh, H.; Kuno, T.
    The MAPK kinase Pek1 acts as a phosphorylation-dependent molecular switch (1999), Nature, 399, 479-483.
    View publication on PubMed
Search for more literature for 2.7.12.2

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + protein Schizosaccharomyces pombe Pek1, in its unphosphorylated form, acts as a potent negative regulator of Pmk1 MAPK signalling. Mkh1, an upstream MAPKK kinase, converts Pek1 from being an inhibitor to an activator. Pek1 has a dual stimulatory and inhibitory function which depends on its phosphorylation state ADP + phosphoprotein
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Organism

Organism UniProt Comment Textmining
Schizosaccharomyces pombe Q9Y884
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Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein Pek1 has a dual stimulatory and inhibitory function which depends on its phosphorylation state Schizosaccharomyces pombe

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + protein Pek1, in its unphosphorylated form, acts as a potent negative regulator of Pmk1 MAPK signalling. Mkh1, an upstream MAPKK kinase, converts Pek1 from being an inhibitor to an activator. Pek1 has a dual stimulatory and inhibitory function which depends on its phosphorylation state Schizosaccharomyces pombe ADP + phosphoprotein
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 ?
additional information Pek1, in its unphosphorylated form, acts as a potent negative regulator of Pmk1 MAPK signalling. Mkh1, an upstream MAPKK kinase, converts Pek1 from being an inhibitor to an activator. Pek1 has a dual stimulatory and inhibitory function which depends on its phosphorylation state Schizosaccharomyces pombe ?
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Synonyms

Synonyms Comment Organism
MAP kinase kinase skh1/pek1
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 Schizosaccharomyces pombe