Literature summary for 2.7.12.2 extracted from

Wang, X.S.; Diener, K.; Jannuzzi, D.; Trollinger, D.; Tan, T.H.; Lichenstein, H.; Zukowski, M.; Yao, Z.
Molecular cloning and characterization of a novel protein kinase with a catalytic domain homologous to mitogen-activated protein kinase kinase kinase (1996), J. Biol. Chem., 271, 31607-31611.

Search for more literature for 2.7.12.2

Cloned(Commentary)

Cloned (Comment)	Organism
expression in COS and 293 cells	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + protein	Homo sapiens	MAPKKK5 may be an upstream activator of MKK4 in the c-Jun N-terminal kinase pathway	ADP + phosphoprotein	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q99683	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
macrophage	-	Homo sapiens	-
pancreas	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + MKK4	-	Homo sapiens	ADP + phosphorylated MKK4	-	?
ATP + protein	MAPKKK5 may be an upstream activator of MKK4 in the c-Jun N-terminal kinase pathway	Homo sapiens	ADP + phosphoprotein	-	?

Synonyms

Synonyms	Comment	Organism
mitogen-activated protein kinase kinase kinase 5	-	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)