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Literature summary for 2.7.12.2 extracted from
- Cloning and characterization of MEK6, a novel member of the mitogen-activated protein kinase kinase cascade (1996), J. Biol. Chem., 271, 11427-11433.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| anisomycin | activates | Homo sapiens |  |
| additional information | MEK6 is strongly activated by UV, anisomycin, and osmotic shock | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + protein | Homo sapiens | MEK6 is a member of the p38 kinase cascade and efficiently phosphorylates p38, induces phosphorylation of ATF2 by p38 but does not phosphorylate ATF2 directly | ADP + phosphoprotein | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P52564 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + p38 | - |
Homo sapiens | ADP + ? | - |
? | |
| ATP + protein | MEK6 is a member of the p38 kinase cascade and efficiently phosphorylates p38, induces phosphorylation of ATF2 by p38 but does not phosphorylate ATF2 directly | Homo sapiens | ADP + phosphoprotein | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| dual specificity mitogen-activated protein kinase kinase 6 | - |
Homo sapiens |
| MKK6 | - |
Homo sapiens |
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