Literature summary for 2.7.12.2 extracted from

Duesbery, N.S.; Webb, C.P.; Leppla, S.H.; Gordon, V.M.; Klimpel, K.R.; Copeland, T.D.; Ahn, N.G.; Oskarsson, M.K.; Fukasawa, K.; Paull, K.D.; Vande Woude, G.F.
Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor (1998), Science, 280, 734-737.

Search for more literature for 2.7.12.2

General Stability

General Stability	Organism
proteolytic inactivation by anthrax lethal factor	Mus musculus
proteolytic inactivation by anthrax lethal factor	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + protein	Mus musculus	enzyme is involved on MAPK signal transduction pathway	ADP + phosphoprotein	-	?
ATP + protein	Homo sapiens	enzyme is involved on MAPK signal transduction pathway	ADP + phosphoprotein	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P36507	-	-
Homo sapiens	Q02750	-	-
Mus musculus	P31938	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + protein	enzyme is involved on MAPK signal transduction pathway	Mus musculus	ADP + phosphoprotein	-	?
ATP + protein	enzyme is involved on MAPK signal transduction pathway	Homo sapiens	ADP + phosphoprotein	-	?

Synonyms

Synonyms	Comment	Organism
dual specificity mitogen-activated protein kinase kinase 1	-	Mus musculus
dual specificity mitogen-activated protein kinase kinase 1	-	Homo sapiens
dual specificity mitogen-activated protein kinase kinase 2	-	Homo sapiens
MAPKK1	-	Mus musculus
MAPKK2	-	Homo sapiens

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Release 2023.1 (January 2023)