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Literature summary for 2.7.11.4 extracted from

  • Reed, L.J.; Damuni, Z.; Merryfield, M.L.
    Regulation of mammalian pyruvate and branched-chain alpha-keto acid dehydrogenase complexes by phosphorylation-dephosphorylation (1985), Curr. Top. Cell. Regul., 27, 41-49.
    View publication on PubMed
Search for more literature for 2.7.11.4

Activating Compound

Activating Compound Comment Organism Structure
histone H3 1.5 to 3fold Oryctolagus cuniculus
poly-L-arginine 1.5 to 3fold Oryctolagus cuniculus
poly-L-lysine 1.5 to 3fold Oryctolagus cuniculus
protamine 1.5 to 3fold Oryctolagus cuniculus

Inhibitors

Inhibitors Comment Organism Structure
acyl-CoA
-
 Oryctolagus cuniculus
ADP 50% inhibition at 0.4 mM, inhibition can be reversed by 2 mM Mg2+ Bos taurus
ADP 50% inhibition at 0.4 mM, inhibition can be reversed by 2 mM Mg2+ Oryctolagus cuniculus
ADP 50% inhibition at 0.4 mM, inhibition can be reversed by 2 mM Mg2+ Rattus norvegicus
ATP 50% inhibition at 0.2 mM, inhibition can be reversed by 2 mM Mg2+ Oryctolagus cuniculus
ATP
-
 Rattus norvegicus
branched-chain 2-oxo acids
-
 Bos taurus
branched-chain 2-oxo acids
-
 Oryctolagus cuniculus
branched-chain 2-oxo acids
-
 Rattus norvegicus
CDP 50% inhibition at 0.4 mM, inhibition can be reversed by 2 mM Mg2+ Oryctolagus cuniculus
CoA
-
 Oryctolagus cuniculus
CTP 50% inhibition at 0.25 mM, inhibition can be reversed by 2 mM Mg2+ Oryctolagus cuniculus
GDP 50% inhibition at 0.2 mM, inhibition can be reversed by 2 mM Mg2+ Oryctolagus cuniculus
GTP 50% inhibition at 0.06 mM, inhibition can be reversed by 2 mM Mg2+ Oryctolagus cuniculus
heparin 50% inhibition at 0.002 mM Oryctolagus cuniculus
additional information no inhibition by coenzyme A; no inhibition by isovaleryl-CoA Bos taurus
additional information no inhibition by isovaleryl-CoA Oryctolagus cuniculus
additional information no inhibition by isovaleryl-CoA Rattus norvegicus
thiamine diphosphate
-
 Bos taurus
thiamine diphosphate
-
 Oryctolagus cuniculus
thiamine diphosphate
-
 Rattus norvegicus
UDP 50% inhibition at 0.25 mM, inhibition can be reversed by 2 mM Mg2+ Oryctolagus cuniculus
UTP 50% inhibition at 0.1 mM, inhibition can be reversed by 2 mM Mg2+ Oryctolagus cuniculus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Rattus norvegicus 5739
-
mitochondrion
-
 Bos taurus 5739
-
mitochondrion
-
 Oryctolagus cuniculus 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
460000
-
 gel filtration Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] Rattus norvegicus phosphorylation inactivates EC 1.2.4.4 ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate
-
 ?
ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] Bos taurus phosphorylation inactivates EC 1.2.4.4 ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate
-
 ?
ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] Oryctolagus cuniculus phosphorylation inactivates EC 1.2.4.4 ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Oryctolagus cuniculus
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Rattus norvegicus
-
kidney
-
 Bos taurus
-
kidney
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] 2 Ser-residues in E1-alpha-subunit Rattus norvegicus ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate
-
 ?
ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] 2 Ser-residues in E1-alpha-subunit Bos taurus ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate
-
 ?
ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] 2 Ser-residues in E1-alpha-subunit Oryctolagus cuniculus ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate
-
 ?
ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphorylation inactivates EC 1.2.4.4 Rattus norvegicus ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate
-
 ?
ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphorylation inactivates EC 1.2.4.4 Bos taurus ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate
-
 ?
ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphorylation inactivates EC 1.2.4.4 Oryctolagus cuniculus ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate
-
 ?