Crystallization (Comment) | Organism |
---|---|
in complex with (S)-alpha-chloro-phenylpropionic acid, hanging drop vapor diffusion method, using 12% (w/v) PEG-8000, 0.1 M Tris·HCl, pH 8.5, 1.3-1.5 M NaCl | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2R)-2-chloro-3-phenylpropanoic acid | - |
Mus musculus | |
(2S)-2-chloro-3-phenylpropanoic acid | - |
Mus musculus | |
(R)-alpha-chloroisocaproate | - |
Mus musculus | |
(S)-alpha-chloroisocaproate | - |
Mus musculus | |
2-oxoisocaproate | - |
Mus musculus | |
Clofibric acid | - |
Mus musculus | |
Hydrocinnamic acid | - |
Mus musculus | |
methylhydrocinnamic acid | - |
Mus musculus | |
phenylacetate | - |
Mus musculus | |
phenylbutyrate | - |
Mus musculus | |
phenylpyruvic acid | - |
Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Mus musculus | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] | Mus musculus | - |
ADP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | O55028 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] | - |
Mus musculus | ADP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
BCKD kinase | - |
Mus musculus |
BDK | - |
Mus musculus |
branched-chain alpha-ketoacid dehydrogenase kinase | - |
Mus musculus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0063 | - |
at pH 7.5 and 25°C | Mus musculus | (2S)-2-chloro-3-phenylpropanoic acid | |
0.012 | - |
at pH 7.5 and 25°C | Mus musculus | (R)-alpha-chloroisocaproate | |
0.0214 | - |
at pH 7.5 and 25°C | Mus musculus | (2R)-2-chloro-3-phenylpropanoic acid | |
0.0338 | - |
at pH 7.5 and 25°C | Mus musculus | methylhydrocinnamic acid | |
0.0431 | - |
at pH 7.5 and 25°C | Mus musculus | Hydrocinnamic acid | |
0.0531 | - |
at pH 7.5 and 25°C | Mus musculus | phenylbutyrate | |
0.0534 | - |
at pH 7.5 and 25°C | Mus musculus | (S)-alpha-chloroisocaproate | |
0.0749 | - |
at pH 7.5 and 25°C | Mus musculus | 2-oxoisocaproate | |
0.346 | - |
at pH 7.5 and 25°C | Mus musculus | phenylpyruvic acid | |
0.812 | - |
at pH 7.5 and 25°C | Mus musculus | Clofibric acid | |
1.27 | - |
at pH 7.5 and 25°C | Mus musculus | phenylacetate |