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Literature summary for 2.7.11.4 extracted from

  • Doisaki, M.; Katano, Y.; Nakano, I.; Hirooka, Y.; Itoh, A.; Ishigami, M.; Hayashi, K.; Goto, H.; Fujita, Y.; Kadota, Y.; Kitaura, Y.; Bajotto, G.; Kazama, S.; Tamura, T.; Tamura, N.; Feng, G.G.; Ishikawa, N.; Shimomura, Y.
    Regulation of hepatic branched-chain alpha-keto acid dehydrogenase kinase in a rat model for type 2 diabetes mellitus at different stages of the disease (2010), Biochem. Biophys. Res. Commun., 393, 303-307.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
BDK quantitative real-time PCR expression analysis Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] Rattus norvegicus inactivation by phosphorylation of BCKDH ADP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] phosphate
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte
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Rattus norvegicus
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liver activity of BDK is higher in fatty diabetic rats than in lean non-diabetic rats Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] inactivation by phosphorylation of BCKDH Rattus norvegicus ADP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] phosphate
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?

Synonyms

Synonyms Comment Organism
BCKDH kinase
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Rattus norvegicus
BDK
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Rattus norvegicus
branched-chain alpha-keto acid dehydrogenase kinase
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Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
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Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus insulin is known to increase the enzyme expression in cultured rat hepatocytes up

General Information

General Information Comment Organism
malfunction the BDK activity is decreased in the livers of streptozotocin-induced diabetic rats Rattus norvegicus
additional information activity of BDK practically corresponds with plasma insulin concentrations Rattus norvegicus
physiological function branched-chain alpha-keto acid dehydrogenase kinase is responsible for the regulation of branched-chain alpha-keto acid dehydrogenase complex, which is the rate-limiting enzyme in the catabolism of branched-chain amino acids Rattus norvegicus