Cloned (Comment) | Organism |
---|---|
BDK quantitative real-time PCR expression analysis | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] | Rattus norvegicus | inactivation by phosphorylation of BCKDH | ADP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hepatocyte | - |
Rattus norvegicus | - |
liver | activity of BDK is higher in fatty diabetic rats than in lean non-diabetic rats | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] | inactivation by phosphorylation of BCKDH | Rattus norvegicus | ADP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
BCKDH kinase | - |
Rattus norvegicus |
BDK | - |
Rattus norvegicus |
branched-chain alpha-keto acid dehydrogenase kinase | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Rattus norvegicus | insulin is known to increase the enzyme expression in cultured rat hepatocytes | up |
General Information | Comment | Organism |
---|---|---|
malfunction | the BDK activity is decreased in the livers of streptozotocin-induced diabetic rats | Rattus norvegicus |
additional information | activity of BDK practically corresponds with plasma insulin concentrations | Rattus norvegicus |
physiological function | branched-chain alpha-keto acid dehydrogenase kinase is responsible for the regulation of branched-chain alpha-keto acid dehydrogenase complex, which is the rate-limiting enzyme in the catabolism of branched-chain amino acids | Rattus norvegicus |