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Literature summary for 2.7.11.4 extracted from

  • Akita, K.; Fujimura, Y.; Bajotto, G.; Shimomura, Y.
    Inhibition of branched-chain alpha-ketoacid dehydrogenase kinase by thiamine pyrophosphate at different potassium ionic levels (2009), Biosci. Biotechnol. Biochem., 73, 1189-1191.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
alpha-Chloroisocaproate
-
Rattus norvegicus
thiamine diphosphate
-
Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
K+
-
Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
Rattus norvegicus
-
liver
-
Rattus norvegicus
-

Synonyms

Synonyms Comment Organism
branched-chain alpha-ketoacid dehydrogenase kinase
-
Rattus norvegicus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0032
-
thiamine diphosphate 20 mM K+ Rattus norvegicus
0.0164
-
thiamine diphosphate 100 mM K+ Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0046
-
20 mM K+ Rattus norvegicus thiamine diphosphate
0.006
-
100 mM K+ Rattus norvegicus alpha-Chloroisocaproate
0.008
-
100 mM K+ Rattus norvegicus thiamine diphosphate
0.031
-
10 mM K+ Rattus norvegicus alpha-Chloroisocaproate