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Literature summary for 2.7.11.4 extracted from
- Cross-talk between thiamin diphosphate binding and phosphorylation loop conformation in human branched-chain alpha-keto acid decarboxylase/dehydrogenase (2004), J. Biol. Chem., 279, 32968-32978.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | binding of thiamin diphosphate cofactor to branched-chain alpha-keto acid decarboxylase/dehydrogenase, which induces a phosphorylation loop conformation change, inhibits the phosphorylation of the protein by the BCKD kinase, no inhibition of phosphorylation of mutant R287A, D295A, Y300F, and R301A E1B components | Rattus norvegicus |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Rattus norvegicus |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + branched-chain alpha-keto acid decarboxylase/dehydrogenase | Rattus norvegicus | inactivation of the substrate enzyme | ADP + phosphorylated branched-chain alpha-keto acid decarboxylase/dehydrogenase | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + branched-chain alpha-keto acid decarboxylase/dehydrogenase | inactivation of the substrate enzyme | Rattus norvegicus | ADP + phosphorylated branched-chain alpha-keto acid decarboxylase/dehydrogenase | - |
? | |
| ATP + branched-chain alpha-keto acid decarboxylase/dehydrogenase | recombinant human wild-type and mutant substrate proteins, overview, phosphorylation at Ser301 and Ser302 in the phosphorylation loop of decarboxylase E1b component of the large branched-chain alpha-keto acid dehydrogenase complex, loop structure, overview | Rattus norvegicus | ADP + phosphorylated branched-chain alpha-keto acid decarboxylase/dehydrogenase | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| BCKD kinase | - |
Rattus norvegicus |
| branched-chain alpha-keto acid decarboxylase/dehydrogenase kinase | - |
Rattus norvegicus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 22 | - |
assay at room temperature | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Rattus norvegicus | |
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Release 2023.1 (January 2023)
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