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Literature summary for 2.7.11.31 extracted from

  • Choi, H.C.; Song, P.; Xie, Z.; Wu, Y.; Xu, J.; Zhang, M.; Dong, Y.; Wang, S.; Lau, K.; Zou, M.H.
    Reactive nitrogen species is required for the activation of the AMP-activated protein kinase by statin in vivo (2008), J. Biol. Chem., 283, 20186-20197.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
(+)-simvastatin 0.05 mM increases phosphorylation of AMPK at Thr172 by 2.6fold and acetyl-CoA carboxylase at Ser79 in BAEC. Ser428 phosphorylation of LKB1 is essential for statin-induced AMPK activation. Statin-induced AMPK activation in BAEC is independent of CaMKKbeta. Activation of AMPK by statin Is O2- or ONOO- dependent Bos taurus
(+)-simvastatin in vivo administration of statin increases 3-nitrotyrosine and the phosphorylation of AMPK and acetyl-CoA carboxylase in wild-type mice but not in mice deficient in endothelial nitric-oxide synthase. PKC-zeta-dependent AMPK activation. In vivo transfection of PKC-zeta-specific small interfering RNA in mice significantly attenuates statin-enhanced phosphorylation of AMPK-Thr172, acetyl-CoA carboxylase-Ser79, and LKB1-Ser428 Mus musculus
(+)-simvastatin LKB1 is required for statin-dependent AMPK activation. Transfection of LKB1-expressing plasmid is required for statin-induced AMPK activation in A-549 and HeLa S3 cell lines deficient in endogenous LKB1 Homo sapiens
A23187 0.01 mM significantly enhances the phosphorylation of AMPK-Thr172 in BAEC. Either STO-609 (0.001 mM) or BAPTA-AM (0.02 mM), significantly suppresses calcium inophore A23187-enhanced phosphorylation in BAEC Bos taurus
metformin significantly increases AMPK activity in the aortas and hearts of wild-type mice but not those of eNOS-/-, although eNOS-/- mice express AMPK Mus musculus
Mito-TEMPOL mitochondria-targeting superoxide dismutase mimetic, 0.01 mM markedly attenuates statin-enhanced phosphorylation of both AMPK-Thr172 and acetyl-CoA carboxylase-Ser79 Bos taurus
additional information ONOO- dependent activation of AMPK Mus musculus
PKC-zeta is required for statin-induced LKB1 nucleus export and AMPK activation in HUVEC cells Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
BAEC infected with adenovirus expressing an AMPK dominant negative mutant Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
6-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-3-pyridin-4-yl-pyrrazolo[1,5-a]-pyrimidine compound C, abolishes statin-induced reduction of O2- in BAEC Bos taurus
additional information genetic inhibition of LKB1 ablates statin-induced AMPK activation in endothelial cells Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Homo sapiens
-
-
-
Mus musculus
-
C57BL/6J mice
-
Mus musculus C57/BL6J
-
C57BL/6J mice
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
Homo sapiens
-
aorta
-
Mus musculus
-
aortic endothelial cell
-
Bos taurus
-
BAEC cell
-
Bos taurus
-
heart
-
Mus musculus
-
HeLa-S3 cell
-
Homo sapiens
-
HUVEC cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + acetyl-CoA carboxylase
-
Mus musculus ADP + phosphorylated acetyl-CoA carboxylase
-
?
ATP + acetyl-CoA carboxylase
-
Mus musculus C57/BL6J ADP + phosphorylated acetyl-CoA carboxylase
-
?
ATP + acetyl-CoA carboxylase
-
Homo sapiens ADP + [acetyl-CoA carboxylase]phosphate
-
?
ATP + acetyl-CoA carboxylase
-
Bos taurus ADP + [acetyl-CoA carboxylase]phosphate
-
?

Synonyms

Synonyms Comment Organism
AMP-activated protein kinase
-
Mus musculus
AMP-activated protein kinase
-
Homo sapiens
AMP-activated protein kinase
-
Bos taurus
AMPK
-
Mus musculus
AMPK
-
Homo sapiens
AMPK
-
Bos taurus

Expression

Organism Comment Expression
Bos taurus overexpression of AMPK dominant negative mutant abolishes statin-induced reduction of O2- in BAEC additional information

General Information

General Information Comment Organism
physiological function AMPK activation inhibits endothelial apoptosis in cultured cells. AMPK activation suppresses the basal and angiotensin II-enhanced superoxide anions in BAEC Bos taurus