Literature summary for 2.7.11.31 extracted from

Hamilton, S.R.; Stapleton, D.; O'Donnell, J.B.; Kung, J.T.; Dalal, S.R.; Kemp, B.E.; Witters, L.A.
An activating mutation in the g1 subunit of the AMP-activated protein kinase (2001), FEBS Lett., 500, 163-168.

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Activating Compound

Activating Compound	Comment	Organism	Structure
5'-AMP	-	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
AMPK heterotrimer expressed in COS7 cells	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
R70Q	site-directed mutagenesis, marked increase in activity, largely AMP-independent	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + acetyl-CoA carboxylase	-	Homo sapiens	ADP + [acetyl-CoA carboxylase] phosphate	-	?

Subunits

Subunits	Comment	Organism
heterotrimer	-	Homo sapiens
More	heterotrimeric serine/threonine kinase consists of a catalytic alpha-subunit and 2 regulatory subunits beta and gamma, each subunit exists as multiple isoforms, alpha1, alpha2, beta1, beta2, gamma1, gamma2 and gamma3, giving 12 different possible combinantions of holoenzyme with different tissue distribution and subcellular localization	Homo sapiens

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Release 2023.1 (January 2023)