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Literature summary for 2.7.11.31 extracted from
- AMP-activated protein kinase regulation of fatty acid oxidation in the ischaemic heart (2003), Biochem. Soc. Trans., 31, 207-212.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| 5'-AMP | - |
Homo sapiens |  |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | decreasing the ischaemic-induced activation of AMPK may be a therapeutic approach to treating ischaemic heart disease, AMPK may be an important pharmacological target for improving cardiac efficiency following ischaemia | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
human | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| heart | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + acetyl-CoA carboxylase | AMPK plays an important role in regulating malonyl-CoA levels through the phosphorylation of acetyl-CoA carboxylase | Homo sapiens | ADP + [acetyl-CoA carboxylase] phosphate | - |
? | |
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