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Literature summary for 2.7.11.30 extracted from

  • Xu, G.; Bernaudo, S.; Fu, G.; Lee, D.Y.; Yang, B.B.; Peng, C.
    Cyclin G2 is degraded through the ubiquitin-proteasome pathway and mediates the antiproliferative effect of activin receptor-like kinase 7 (2008), Mol. Biol. Cell, 19, 4968-4979.
    View publication on PubMedView publication on EuropePMC

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [actividin receptor] Homo sapiens
-
ADP + [actividin receptor] phosphate
-
?
additional information Homo sapiens cyclin G2 mRNA is strongly up-regulated by Nodal and ALK7, Nodal and ALK7 decrease the expression of Skp1 and Skp2 and increase cyclin G2 levels. The antiproliferative effect of Nodal/ALK7 on ovarian cancer cells is in part mediated by cyclin G2, regulation, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
IOSE-397 cell an ovarian surface epithelial cell line Homo sapiens
-
IOSE-398 cell an ovarian surface epithelial cell line Homo sapiens
-
OV-2008 cell an ovarian cancer cell line Homo sapiens
-
ovarian cancer cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [actividin receptor]
-
Homo sapiens ADP + [actividin receptor] phosphate
-
?
additional information cyclin G2 mRNA is strongly up-regulated by Nodal and ALK7, Nodal and ALK7 decrease the expression of Skp1 and Skp2 and increase cyclin G2 levels. The antiproliferative effect of Nodal/ALK7 on ovarian cancer cells is in part mediated by cyclin G2, regulation, overview Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
activin receptor-like kinase 7
-
Homo sapiens
ALK7
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens