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Literature summary for 2.7.11.30 extracted from

  • Zhao, S.; Ammanamanchi, S.; Brattain, M.; Cao, L.; Thangasamy, A.; Wang, J.; Freeman, J.W.
    Smad4-dependent TGF-beta signaling suppresses RON receptor tyrosine kinase-dependent motility and invasion of pancreatic cancer cells (2008), J. Biol. Chem., 283, 11293-11301.
    View publication on PubMedView publication on EuropePMC
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Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [TGF-beta receptor I] Homo sapiens TGF-beta signalling pathway regulation, overview ADP + [TGF-beta receptor I] phosphate
-
 ?
additional information Homo sapiens signaling by RON, a phosphotyrosine kinase receptor, cooperates with Smad4-independent TGF-beta signaling to promote cell motility and invasion, knocking down RON expression in Smad4-deficient cells suppresses TGF-beta-mediated motility and invasion. Functional inactivation by site-directed mutations of two Smad binding sites on the RON promoter inhibits TGF-beta-mediated repression of RON promoter activity, cross-talk of Smad4-independent TGF-beta signaling and the RON pathway promotes an invasive phenotype, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
AsPC-1 cell
-
 Homo sapiens
-
BxPC-3 cell
-
 Homo sapiens
-
CAPAN-2 cell
-
 Homo sapiens
-
CFPAC-1 cell
-
 Homo sapiens
-
MiaPaCa-2 cell
-
 Homo sapiens
-
PANC-1 cell
-
 Homo sapiens
-
pancreatic ductal adenocarcinoma cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [TGF-beta receptor I]
-
 Homo sapiens ADP + [TGF-beta receptor I] phosphate
-
 ?
ATP + [TGF-beta receptor I] TGF-beta signalling pathway regulation, overview Homo sapiens ADP + [TGF-beta receptor I] phosphate
-
 ?
additional information signaling by RON, a phosphotyrosine kinase receptor, cooperates with Smad4-independent TGF-beta signaling to promote cell motility and invasion, knocking down RON expression in Smad4-deficient cells suppresses TGF-beta-mediated motility and invasion. Functional inactivation by site-directed mutations of two Smad binding sites on the RON promoter inhibits TGF-beta-mediated repression of RON promoter activity, cross-talk of Smad4-independent TGF-beta signaling and the RON pathway promotes an invasive phenotype, overview Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
TGF-beta type I receptor kinase
-
 Homo sapiens
transforming growth factor-beta type 1 receptor kinase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens