Inhibitors | Comment | Organism | Structure |
---|---|---|---|
LY2157299 | inhibits Smad3 and Smad3 phosphorylation and antagonizes TGF-beta receptor I kinase activity in vivo in human cancer cells implanted into nude mice, pharmacokinetic model, overview | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [TGF-beta receptor I] | Homo sapiens | - |
ADP + [TGF-beta receptor I] phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast carcinoma cell | - |
Homo sapiens | - |
Calu-6 cell | anaplastic carcinoma lung cell | Homo sapiens | - |
MX-1 cell | carcinoma breast cell | Homo sapiens | - |
non-small cell lung cancer cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [TGF-beta receptor I] | - |
Homo sapiens | ADP + [TGF-beta receptor I] phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
type I receptor TGF-beta kinase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |