Activating Compound | Comment | Organism | Structure |
---|---|---|---|
growth differentiation factor-9 | i.e. GDF-9, interacts with bone morphogenetic protein type II receptor, and activates type I actividin receptor-like kinase 5, ALK5, GDF-9 belongs to the TGF-beta family, no stimulation of receptors ALK1, ALK2, ALK3, and ALKA6 by GDF-9 | Rattus norvegicus | |
TGF-beta | interacts with and activates type I actividin receptor-like kinase 5, ALK5 | Rattus norvegicus |
Cloned (Comment) | Organism |
---|---|
expressed in P-19 cells | Rattus norvegicus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | conferring of responsiveness to GDF-9-mediated stimulation of ALK5 and Smad3 phosphorylation in normally unresponsive COS-7 cells by overexpression of the three proteins, no responsiveness by co-expression with BMPRII receptor, expression of GDF-9 in a CAGA-luciferase reporter construct in P19 cells reveals that GDF-9 binds to BMP-activated type II receptors but its downstream actions are mediated by the type I receptor ALK5, overview, expression of ALK5 siRNA inhibits GDF-9-induced stimulation in granulosa cells | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | no inhibition of GDF-9-induced receptor activation by Smad6 | Rattus norvegicus | |
Smad7 | inhibits induction of receptor activation/signaling by GDF-9 in vivo | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Rattus norvegicus | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + Smad2 | Rattus norvegicus | GDF-9-induced phosphorylation | ADP + phosphorylated Smad2 | - |
? | |
ATP + Smad3 | Rattus norvegicus | GDF-9-induced phosphorylation | ADP + phosphorylated Smad3 | - |
? | |
additional information | Rattus norvegicus | diverse ligand members of the TGF-beta family interact with a limited number of receptors in a combinatorial manner to activate two downstream Smad pathways | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | P80204 | female Sprague-Dawley rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
granulosa cell | - |
Rattus norvegicus | - |
ovarian follicle | small antral follicle of estrogen-treated rats | Rattus norvegicus | - |
ovary | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + Smad2 | GDF-9-induced phosphorylation | Rattus norvegicus | ADP + phosphorylated Smad2 | - |
? | |
ATP + Smad3 | GDF-9-induced phosphorylation | Rattus norvegicus | ADP + phosphorylated Smad3 | - |
? | |
additional information | diverse ligand members of the TGF-beta family interact with a limited number of receptors in a combinatorial manner to activate two downstream Smad pathways | Rattus norvegicus | ? | - |
? | |
additional information | GDF-9 does not induce phosphorylation of Smad1 | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
activin receptor-like kinase 5 | - |
Rattus norvegicus |
ALK5 | - |
Rattus norvegicus |
BM-PRI | - |
Rattus norvegicus |
BM-PRII | - |
Rattus norvegicus |
BMP type I receptor | - |
Rattus norvegicus |
BMP type II receptor | - |
Rattus norvegicus |
bone morphogenetic protein type II receptor | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Rattus norvegicus |