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Literature summary for 2.7.11.30 extracted from

  • Mazerbourg, S.; Klein, C.; Roh, J.; Kaivo-Oja, N.; Mottershead, D.G.; Korchynskyi, O.; Ritvos, O.; Hsueh, A.J.
    Growth differentiation factor-9 signaling is mediated by the type I receptor, activin receptor-like kinase 5 (2004), Mol. Endocrinol., 18, 653-665.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
growth differentiation factor-9 i.e. GDF-9, interacts with bone morphogenetic protein type II receptor, and activates type I actividin receptor-like kinase 5, ALK5, GDF-9 belongs to the TGF-beta family, no stimulation of receptors ALK1, ALK2, ALK3, and ALKA6 by GDF-9 Rattus norvegicus
TGF-beta interacts with and activates type I actividin receptor-like kinase 5, ALK5 Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
expressed in P-19 cells Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
additional information conferring of responsiveness to GDF-9-mediated stimulation of ALK5 and Smad3 phosphorylation in normally unresponsive COS-7 cells by overexpression of the three proteins, no responsiveness by co-expression with BMPRII receptor, expression of GDF-9 in a CAGA-luciferase reporter construct in P19 cells reveals that GDF-9 binds to BMP-activated type II receptors but its downstream actions are mediated by the type I receptor ALK5, overview, expression of ALK5 siRNA inhibits GDF-9-induced stimulation in granulosa cells Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
additional information no inhibition of GDF-9-induced receptor activation by Smad6 Rattus norvegicus
Smad7 inhibits induction of receptor activation/signaling by GDF-9 in vivo Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Rattus norvegicus 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + Smad2 Rattus norvegicus GDF-9-induced phosphorylation ADP + phosphorylated Smad2
-
?
ATP + Smad3 Rattus norvegicus GDF-9-induced phosphorylation ADP + phosphorylated Smad3
-
?
additional information Rattus norvegicus diverse ligand members of the TGF-beta family interact with a limited number of receptors in a combinatorial manner to activate two downstream Smad pathways ?
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus P80204 female Sprague-Dawley rats
-

Source Tissue

Source Tissue Comment Organism Textmining
granulosa cell
-
Rattus norvegicus
-
ovarian follicle small antral follicle of estrogen-treated rats Rattus norvegicus
-
ovary
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + Smad2 GDF-9-induced phosphorylation Rattus norvegicus ADP + phosphorylated Smad2
-
?
ATP + Smad3 GDF-9-induced phosphorylation Rattus norvegicus ADP + phosphorylated Smad3
-
?
additional information diverse ligand members of the TGF-beta family interact with a limited number of receptors in a combinatorial manner to activate two downstream Smad pathways Rattus norvegicus ?
-
?
additional information GDF-9 does not induce phosphorylation of Smad1 Rattus norvegicus ?
-
?

Synonyms

Synonyms Comment Organism
activin receptor-like kinase 5
-
Rattus norvegicus
ALK5
-
Rattus norvegicus
BM-PRI
-
Rattus norvegicus
BM-PRII
-
Rattus norvegicus
BMP type I receptor
-
Rattus norvegicus
BMP type II receptor
-
Rattus norvegicus
bone morphogenetic protein type II receptor
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
Rattus norvegicus