Activating Compound | Comment | Organism | Structure |
---|---|---|---|
TGF-beta | activates the TGF-beta type I receptor kinase by binding, affects BGN and GADDbeta45 expression in PANC-1 and M-63 cells via ALK5 and Smad phosphorylation/activation, overview | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Homo sapiens | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + Smad | Homo sapiens | involved in ALK5 activation of p38 MAPK signaling and of GADDbeta45 and BGN expression induced by TGF-beta | ADP + phosphorylated Smad | - |
? | |
additional information | Homo sapiens | the TGF-beta type I receptor/ALK5-dependent activation of the GADD45beta gene mediates the induction of biglycan expression by TGF-beta, th TGF-beta type II receptor is required for for TGF-beta binding and signaling induction activity, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
MG-63 cell | osteosarcoma cell line | Homo sapiens | - |
osteosarcoma cell | - |
Homo sapiens | - |
PANC-1 cell | pancreatic cancer cell line | Homo sapiens | - |
pancreatic cancer cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + Smad | - |
Homo sapiens | ADP + phosphorylated Smad | - |
? | |
ATP + Smad | involved in ALK5 activation of p38 MAPK signaling and of GADDbeta45 and BGN expression induced by TGF-beta | Homo sapiens | ADP + phosphorylated Smad | - |
? | |
additional information | the TGF-beta type I receptor/ALK5-dependent activation of the GADD45beta gene mediates the induction of biglycan expression by TGF-beta, th TGF-beta type II receptor is required for for TGF-beta binding and signaling induction activity, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ALK5 | - |
Homo sapiens |
TGF-beta type I receptor | - |
Homo sapiens |
transforming growth factor-beta type I receptor | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |