Activating Compound | Comment | Organism | Structure |
---|---|---|---|
TGF-beta | - |
Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression of HA-tagged wild-type ALK7 in rat FaO hepatoma cells and transiently of HA-tagged ALK mutant T194D in human Hep3B hepatoma cells using the adenovirus infection method, expression leads in both cases to an apoptosis-positive phenotype, expression of inactive ALK7 mutant K222R dos not cause an altered phenotype | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
K222R | inactive mutant | Homo sapiens |
additional information | expression of HA-tagged wild-type ALK7 in rat FaO hepatoma cells and transiently of HA-tagged ALK mutant T194D in human Hep3B hepatoma cells using the adenovirus infection method, expression leads in both cases to an apoptosis-positive phenotype, expression of inactive ALK7 mutant K222R dos not cause an altered phenotype | Homo sapiens |
T194D | constitutive active ALK7 mutant | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | a dominant negative SEK1 mutant abolishes the ALK7-induced apoptosis | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Homo sapiens | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + Smad2 | Homo sapiens | step in the MAPK signaling pathway via JNK and p38 | ADP + phosphorylated Smad2 | - |
? | |
ATP + Smad3 | Homo sapiens | step in the MAPK signaling pathway via JNK and p38 | ADP + phosphorylated Smad3 | - |
? | |
additional information | Homo sapiens | activin receptor-like kinase-7, ALK7, induces apoptosis through activation of MAPKs, e.g. SEK1, in a Smad3-dependent mechanism in hepatoma cells | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEP-3B cell | hepatoma cell line | Homo sapiens | - |
hepatoma cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + Smad2 | step in the MAPK signaling pathway via JNK and p38 | Homo sapiens | ADP + phosphorylated Smad2 | - |
? | |
ATP + Smad2 | phosphorylation by ALK7 | Homo sapiens | ADP + phosphorylated Smad2 | - |
? | |
ATP + Smad3 | step in the MAPK signaling pathway via JNK and p38 | Homo sapiens | ADP + phosphorylated Smad3 | - |
? | |
ATP + Smad3 | phosphorylation by ALK7 | Homo sapiens | ADP + phosphorylated Smad3 | - |
? | |
additional information | activin receptor-like kinase-7, ALK7, induces apoptosis through activation of MAPKs, e.g. SEK1, in a Smad3-dependent mechanism in hepatoma cells | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
activin receptor-like kinase-7 | - |
Homo sapiens |
ALK7 | - |
Homo sapiens |
More | ALK7 is a type I serine/threonine kinase receptor belonging to the TGF-beta family of proteins | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |