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Literature summary for 2.7.11.30 extracted from

  • Kim, B.C.; van Gelder, H.; Kim, T.A.; Lee, H.J.; Baik, K.G.; Chun, H.H.; Lee, D.A.; Choi, K.S.; Kim, S.J.
    Activin receptor-like kinase-7 induces apoptosis through activation of MAPKs in a Smad3-dependent mechanism in hepatoma cells (2004), J. Biol. Chem., 279, 28458-28465.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
TGF-beta
-
Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression of HA-tagged wild-type ALK7 in rat FaO hepatoma cells and transiently of HA-tagged ALK mutant T194D in human Hep3B hepatoma cells using the adenovirus infection method, expression leads in both cases to an apoptosis-positive phenotype, expression of inactive ALK7 mutant K222R dos not cause an altered phenotype Homo sapiens

Protein Variants

Protein Variants Comment Organism
K222R inactive mutant Homo sapiens
additional information expression of HA-tagged wild-type ALK7 in rat FaO hepatoma cells and transiently of HA-tagged ALK mutant T194D in human Hep3B hepatoma cells using the adenovirus infection method, expression leads in both cases to an apoptosis-positive phenotype, expression of inactive ALK7 mutant K222R dos not cause an altered phenotype Homo sapiens
T194D constitutive active ALK7 mutant Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information a dominant negative SEK1 mutant abolishes the ALK7-induced apoptosis Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + Smad2 Homo sapiens step in the MAPK signaling pathway via JNK and p38 ADP + phosphorylated Smad2
-
?
ATP + Smad3 Homo sapiens step in the MAPK signaling pathway via JNK and p38 ADP + phosphorylated Smad3
-
?
additional information Homo sapiens activin receptor-like kinase-7, ALK7, induces apoptosis through activation of MAPKs, e.g. SEK1, in a Smad3-dependent mechanism in hepatoma cells ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEP-3B cell hepatoma cell line Homo sapiens
-
hepatoma cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + Smad2 step in the MAPK signaling pathway via JNK and p38 Homo sapiens ADP + phosphorylated Smad2
-
?
ATP + Smad2 phosphorylation by ALK7 Homo sapiens ADP + phosphorylated Smad2
-
?
ATP + Smad3 step in the MAPK signaling pathway via JNK and p38 Homo sapiens ADP + phosphorylated Smad3
-
?
ATP + Smad3 phosphorylation by ALK7 Homo sapiens ADP + phosphorylated Smad3
-
?
additional information activin receptor-like kinase-7, ALK7, induces apoptosis through activation of MAPKs, e.g. SEK1, in a Smad3-dependent mechanism in hepatoma cells Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
activin receptor-like kinase-7
-
Homo sapiens
ALK7
-
Homo sapiens
More ALK7 is a type I serine/threonine kinase receptor belonging to the TGF-beta family of proteins Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens