Activating Compound | Comment | Organism | Structure |
---|---|---|---|
AMP | activates ACK3, no effect on ACK2 | Rattus norvegicus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
76000 | - |
gel filtration | Rattus norvegicus |
76000 | - |
ACK2 | Rattus norvegicus |
105000 | - |
gel filtration ACK3 | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [acetyl-CoA carboxylase] | Rattus norvegicus | phosphorylates and inactivates acetyl-CoA carboxylase, (EC 6.4.1.2), and is therefore involved in regulation of long chain fatty acid synthesis | ADP + [acetyl-CoA carboxylase] phosphate | - |
? | |
ATP + [acetyl-CoA carboxylase] | Rattus norvegicus | ACK3 and not ACK2 appears to be responsible for acetyl-CoA carboxylase inactivation in lactating mammary gland | ADP + [acetyl-CoA carboxylase] phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
response to 24 h starvation and high fat feeding | - |
Purification (Comment) | Organism |
---|---|
partial purification of ACK2 and ACK3 | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
mammary gland | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [acetyl-CoA carboxylase] | inactivation of carboxylase | Rattus norvegicus | ADP + [acetyl-CoA carboxylase] phosphate | - |
? | |
ATP + [acetyl-CoA carboxylase] | phosphorylates and inactivates acetyl-CoA carboxylase, (EC 6.4.1.2), and is therefore involved in regulation of long chain fatty acid synthesis | Rattus norvegicus | ADP + [acetyl-CoA carboxylase] phosphate | - |
? | |
ATP + [acetyl-CoA carboxylase] | ACK3 and not ACK2 appears to be responsible for acetyl-CoA carboxylase inactivation in lactating mammary gland | Rattus norvegicus | ADP + [acetyl-CoA carboxylase] phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
More | cAMP-dependent protein kinase identified, that phosphorylates and inactivates acetyl-CoA carboxylase in vitro, but appears not to be involved in regulation in vivo | Rattus norvegicus |