Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.11.27 extracted from

  • Munday, M.R.; Hardie, D.G.
    Isolation of three cyclic-AMP-independent acetyl-CoA carboxylase kinases from lactating rat mammary gland and characterization of their effects on enzyme activity (1984), Eur. J. Biochem., 141, 617-627.
    View publication on PubMed
Search for more literature for 2.7.11.27

Activating Compound

Activating Compound Comment Organism Structure
CoA inhibitory Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
AMP 7% inhibition at 0.8 mM Rattus norvegicus
CoA 16% inhibition at 0.1 mM Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Rattus norvegicus 5829
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
76000
-
 gel filtration Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [acetyl-CoA carboxylase] Rattus norvegicus phosphorylates and inactivates acetyl-CoA carboxylase, (EC 6.4.1.2), and is therefore involved in regulation of long chain fatty acid synthesis ADP + [acetyl-CoA carboxylase] phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 Wistar rats
-

Purification (Commentary)

Purification (Comment) Organism
-
 Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
mammary gland
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.008
-
 purified enzyme Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + ATP-citrate lyase
-
 Rattus norvegicus ADP + (ATP-citrate lyase) phosphate
-
 ?
ATP + casein
-
 Rattus norvegicus ADP + phosphocasein
-
 ?
ATP + glycogen synthase
-
 Rattus norvegicus ADP + (glycogen synthase) phosphate
-
 ?
ATP + histone histone H1 and H2B, very high activity with histone H2B Rattus norvegicus ADP + phosphohistone
-
 ?
ATP + phosphorylase kinase poor substrate Rattus norvegicus ADP + (phosphorylase kinase) phosphate
-
 ?
ATP + phosvitin
-
 Rattus norvegicus ADP + phosvitin phosphate
-
 ?
ATP + pyruvate kinase L very poor substrate Rattus norvegicus ADP + (pyruvate kinase L) phosphate
-
 ?
ATP + [acetyl-CoA carboxylase] inactivation of carboxylase Rattus norvegicus ADP + [acetyl-CoA carboxylase] phosphate
-
 ?
ATP + [acetyl-CoA carboxylase] incorporates 1.5 mol phosphate per mol of carboxylase Rattus norvegicus ADP + [acetyl-CoA carboxylase] phosphate
-
 ?
ATP + [acetyl-CoA carboxylase] phosphorylates and inactivates acetyl-CoA carboxylase, (EC 6.4.1.2), and is therefore involved in regulation of long chain fatty acid synthesis Rattus norvegicus ADP + [acetyl-CoA carboxylase] phosphate
-
 ?
additional information no activity with phosphorylase b Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
More phosphorylation by cAMP-dependent protein kinase has the same effect on acetyl-CoA carboxylase activity then phosphorylation with acetyl-CoA carboxylase kinase-2 Rattus norvegicus
More two other cAMP-independent kinases found, that phosphorylate but do not effect acetyl-CoA carboxylase kinase activity Rattus norvegicus