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Literature summary for 2.7.11.26 extracted from

  • Ikezu, S.; Ingraham Dixie, K.L.; Koro, L.; Watanabe, T.; Kaibuchi, K.; Ikezu, T.
    Tau-tubulin kinase 1 and amyloid-beta peptide induce phosphorylation of collapsin response mediator protein-2 and enhance neurite degeneration in Alzheimer disease mouse models (2020), Acta Neuropathol. Commun., 8, 12 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.26

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Mus musculus line 141 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + tau-protein Homo sapiens
-
 ADP + O-phospho-tau-protein
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q5TCY1
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Homo sapiens
-
hippocampus
-
 Homo sapiens
-
neuron
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + tau-protein
-
 Homo sapiens ADP + O-phospho-tau-protein
-
 ?
additional information amyloid beta induces collapsin response mediator protein-2 phosphorylation at threonine 514 in a tau-tubulin kinase 1-dependent manner, and tau-tubulin kinase 1 enhances amyloid beta-induced collapsin response mediator protein-2 phosphorylation in Rho kinase-dependent manner in vitro Homo sapiens ?
-
-

Synonyms

Synonyms Comment Organism
Tau-tubulin kinase 1
-
 Homo sapiens
TTBK1
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function tau-tubulin kinase 1 reduces the neurite length of primary cultured neurons in Rho kinase-dependent manner in vitro Homo sapiens