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Literature summary for 2.7.11.26 extracted from

  • Jiang, J.; Wang, Z.H.; Qu, M.; Gao, D.; Liu, X.P.; Zhu, L.Q.; Wang, J.Z.
    Stimulation of EphB2 attenuates tau phosphorylation through PI3K/Akt-mediated inactivation of glycogen synthase kinase-3beta (2015), Sci. Rep., 5, 11765.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.26

Inhibitors

Inhibitors Comment Organism Structure
additional information activation of EphB2 receptor kinase arrests tau hyperphosphorylation through PI3K-/Akt-mediated GSK-3beta inhibition. EphrinB1/Fc treatment induces tyrosine phosphorylation (activation) of EphB2, while deletion of the tyrosine kinase domain (VM) of EphB2 eliminates the receptor stimulation-induced GSK-3beta inhibition and tau dephosphorylation Homo sapiens
additional information stimulation of EphB2 upregulates PI3K and Akt causing inhibition of GSK-3beta Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Homo sapiens
Mg2+ required Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [tau-protein] Homo sapiens
-
 ADP + O-phospho-[tau-protein]
-
 ?
ATP + [tau-protein] Mus musculus recombinant human tau protein expressed in transgenic mice ADP + O-phospho-[tau-protein]
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P49841
-
-
Mus musculus Q9WV60 human tau transgenic mice Thr231
-

Source Tissue

Source Tissue Comment Organism Textmining
brain the active form of GSK-3beta is co-localized with the neurofibrillary tangles in the Alzheimer disease brains Homo sapiens
-
brain the active form of GSK-3beta is co-localized with the neurofibrillary tangles in the Alzheimer disease brains Mus musculus
-
hippocampus
-
 Homo sapiens
-
hippocampus
-
 Mus musculus
-
neuron
-
 Homo sapiens
-
neuron
-
 Mus musculus
-
SK-N-SH cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [tau-protein]
-
 Homo sapiens ADP + O-phospho-[tau-protein]
-
 ?
ATP + [tau-protein] recombinant human tau protein expressed in transgenic mice Mus musculus ADP + O-phospho-[tau-protein]
-
 ?
ATP + [tau-protein] phosphorylation level of tau at Thr205, Thr231, Ser396 and tau-1 sites Homo sapiens ADP + O-phospho-[tau-protein]
-
 ?
ATP + [tau-protein] phosphorylation level of tau at Thr205, Thr231, Ser396 and tau-1 sites Mus musculus ADP + O-phospho-[tau-protein]
-
 ?

Synonyms

Synonyms Comment Organism
GSK-3beta
-
 Homo sapiens
GSK-3beta
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens
ATP
-
 Mus musculus

General Information

General Information Comment Organism
malfunction Stimulation of EphB2 attenuates tau phosphorylation through PI3K/Akt-mediated inactivation of glycogen synthase kinase-3beta Homo sapiens
malfunction Stimulation of EphB2 attenuates tau phosphorylation through PI3K/Akt-mediated inactivation of glycogen synthase kinase-3beta Mus musculus
physiological function stimulation of GSK-3beta both in vitro and in vivo induces tau hyperphosphorylation with impairments of the cognitive functions, whereas inhibition of GSK-3beta improves tau pathologies and memory deficits. Activation of EphB2 receptor kinase arrests tau hyperphosphorylation through PI3K-/Akt-mediated GSK-3beta inhibition. Activation of GSK-3beta inhibits long-term potentiation and impairs synaptic function Homo sapiens
physiological function stimulation of GSK-3beta both in vitro and in vivo induces tau hyperphosphorylation with impairments of the cognitive functions, whereas inhibition of GSK-3beta improves tau pathologies and memory deficits. Stimulation of EphB2 upregulates PI3K and Akt with inhibition of GSK-3beta. Stimulation of EphB2 attenuates tau phosphorylation both in vitro and in hippocampus of human tau transgenic mice Mus musculus