Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.11.26 extracted from

  • Greco, S.J.; Sarkar, S.; Casadesus, G.; Zhu, X.; Smith, M.A.; Ashford, J.W.; Johnston, J.M.; Tezapsidis, N.
    Leptin inhibits glycogen synthase kinase-3beta to prevent tau phosphorylation in neuronal cells (2009), Neurosci. Lett., 455, 191-194.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
leptin
-
Homo sapiens
LiCl
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
neuronal cell
-
Homo sapiens
-
SH-SY5Y cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + protein tau
-
Homo sapiens ADP + protein tau phosphate
-
?

Synonyms

Synonyms Comment Organism
glycogen synthase kinase-3beta
-
Homo sapiens
GSK-3beta
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens the reduction of tau phosphorylation by treatment with 100 nM leptin is mimicked by the downregulation of GSK-3beta down