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Literature summary for 2.7.11.26 extracted from

  • Takahashi-Yanaga, F.; Sasaguri, T.
    Drug development targeting the glycogen synthase kinase-3beta (GSK-3beta)-mediated signal transduction pathway: Inhibitors of the Wnt/beta-catenin signaling pathway as novel anticancer drugs (2009), J. Pharmacol. Sci., 109, 179-183.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
disheveled protein
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm inactive GSK-3beta Homo sapiens 5737
-
nucleus activated GSK-3beta Homo sapiens 5634
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein the activity of GSK-3beta is decreased by the phosphorylation of Ser9 by Akt Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + beta-catenin
-
Homo sapiens ADP + phosphorylated beta-catenin
-
?
ATP + cyclin D1
-
Homo sapiens ADP + phosphorylated cyclin D1
-
?

Synonyms

Synonyms Comment Organism
glycogen synthase kinase-3beta
-
Homo sapiens
GSK-3beta
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens

General Information

General Information Comment Organism
physiological function activation of GSK-3beta results in the inhibition of the Wnt signaling pathway Homo sapiens