Inhibitors | Comment | Organism | Structure |
---|---|---|---|
disheveled protein | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | inactive GSK-3beta | Homo sapiens | 5737 | - |
nucleus | activated GSK-3beta | Homo sapiens | 5634 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | the activity of GSK-3beta is decreased by the phosphorylation of Ser9 by Akt | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + beta-catenin | - |
Homo sapiens | ADP + phosphorylated beta-catenin | - |
? | |
ATP + cyclin D1 | - |
Homo sapiens | ADP + phosphorylated cyclin D1 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
glycogen synthase kinase-3beta | - |
Homo sapiens |
GSK-3beta | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | activation of GSK-3beta results in the inhibition of the Wnt signaling pathway | Homo sapiens |