Literature summary for 2.7.11.26 extracted from

Wu, C.H.; Yeh, S.H.; Tsay, Y.G.; Shieh, Y.H.; Kao, C.L.; Chen, Y.S.; Wang, S.H.; Kuo, T.J.; Chen, D.S.; Chen, P.J.
Glycogen synthase kinase-3 regulates the phosphorylation of severe acute respiratory syndrome coronavirus nucleocapsid protein and viral replication (2009), J. Biol. Chem., 284, 5229-5239.

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Inhibitors

Inhibitors	Comment	Organism	Structure
kenpaullone	-	Homo sapiens
LiCl	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HEK-293T cell	-	Homo sapiens	-
VERO C1008 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + coronavirus nucleocapsid protein	phosphorylation sites are at Ser177, Ser181, Ser184, Ser185, Ser187, Ser189, Ser191, Ser203, and Ser207	Homo sapiens	ADP + phosphorylated coronavirus nucleocapsid protein	-	?
ATP + JHMV-N protein	phosphorylation sites are at Ser197, Ser201, Ser-205, and Ser-209	Homo sapiens	ADP + phosphorylated JHMV-N protein	-	?

Synonyms

Synonyms	Comment	Organism
glycogen synthase kinase-3	-	Homo sapiens
GSK-3alpha	isoform	Homo sapiens
GSK-3beta	isoform	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	glycogen synthase kinase-3 regulates the phosphorylation of severe acute respiratory syndrome coronavirus nucleocapsid protein and viral replication	Homo sapiens

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Release 2023.1 (January 2023)