Inhibitors | Comment | Organism | Structure |
---|---|---|---|
KRM-189 | 74% inhibition at 0.01 mM, competes with ATP for GSK-3beta, leading to decreased Vmax and constant Km with increasing concentrations of ATP | Homo sapiens | |
KRM-191 | 84% inhibition at 0.01 mM, competes with ATP for GSK-3beta, leading to decreased Vmax and constant Km with increasing concentrations of ATP | Homo sapiens | |
KRM-192 | 75% inhibition at 0.01 mM | Homo sapiens | |
KRM-195 | 80% inhibition at 0.01 mM | Homo sapiens | |
KRM-296 | 65% inhibition at 0.01 mM | Homo sapiens | |
KRM-7777 | 65% inhibition at 0.01 mM | Homo sapiens | |
LiCl | 71% inhibition at 0.01 mM | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P49841 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + beta-catenin | - |
Homo sapiens | ADP + beta-catenin phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
glycogen synthase kinase-3beta | - |
Homo sapiens |
GSK-3beta | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000071 | - |
- |
Homo sapiens | LiCl | |
0.000467 | - |
- |
Homo sapiens | KRM-191 | |
0.000539 | - |
- |
Homo sapiens | KRM-296 | |
0.000548 | - |
- |
Homo sapiens | KRM-189 | |
0.001012 | - |
- |
Homo sapiens | KRM-192 | |
0.001863 | - |
- |
Homo sapiens | KRM-195 | |
0.007149 | - |
- |
Homo sapiens | KRM-7777 |