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Literature summary for 2.7.11.26 extracted from

  • Lambourne, S.L.; Sellers, L.A.; Bush, T.G.; Choudhury, S.K.; Emson, P.C.; Suh, Y.H.; Wilkinson, L.S.
    Increased tau phosphorylation on mitogen-activated protein kinase consensus sites and cognitive decline in transgenic models for Alzheimer's disease and FTDP-17: evidence for distinct molecular processes underlying tau abnormalities (2005), Mol. Cell. Biol., 25, 278-293.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
additional information naturally occurring V717I mutation of the amyloid precursor protein APP in a CT100 fragment of organisms with Alzheimer's disease leads to augmented age-dependent tau phosphorylation, followed by increased activation status of mitogen-activated protein kinase family members, e.g. ERK1/2, p38, and c-Jun NH2-terminal kinase, compared to the wild-type organism, naturally occurring V337M mutation of tau protein of patients suffering from Alzheimer's disease leads to age-dependent memory deficits Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol low activity Mus musculus 5829
-
cytosol low activity Homo sapiens 5829
-
membrane mainly Mus musculus 16020
-
membrane mainly Homo sapiens 16020
-
microtubule
-
Mus musculus 5874
-
microtubule
-
Homo sapiens 5874
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Mus musculus
Mg2+
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [tau-protein] Homo sapiens
-
ADP + O-phospho-[tau-protein]
-
?
ATP + [tau-protein] Mus musculus activity in organisms with mutated APP and tau, not in wild-type, overview ADP + O-phospho-[tau-protein]
-
?
additional information Mus musculus naturally occurring V717I mutation of the amyloid precursor protein APP in a CT100 fragment of mutants leads to augmented age-dependent tau phosphorylation, followed by increased activation status of mitogen-activated protein kinase family members, e.g. ERK1/2, p38, and c-Jun NH2-terminal kinase, compared to the wild-type organism, naturally occurring V337M mutation of tau protein of mutants leads to age-dependent memory deficits ?
-
?
additional information Homo sapiens naturally occurring V717I mutation of the amyloid precursor protein APP in a CT100 fragment of organisms with Alzheimer's disease leads to augmented age-dependent tau phosphorylation, followed by increased activation status of mitogen-activated protein kinase family members, e.g. ERK1/2, p38, and c-Jun NH2-terminal kinase, compared to the wild-type organism, naturally occurring V337M mutation of tau protein of patients suffering from Alzheimer's disease leads to age-dependent memory deficits ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain distribution in brain regions, overview Mus musculus
-
brain distribution in brain regions, overview Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [tau-protein]
-
Mus musculus ADP + O-phospho-[tau-protein]
-
?
ATP + [tau-protein]
-
Homo sapiens ADP + O-phospho-[tau-protein]
-
?
ATP + [tau-protein] activity in organisms with mutated APP and tau, not in wild-type, overview Mus musculus ADP + O-phospho-[tau-protein]
-
?
additional information naturally occurring V717I mutation of the amyloid precursor protein APP in a CT100 fragment of mutants leads to augmented age-dependent tau phosphorylation, followed by increased activation status of mitogen-activated protein kinase family members, e.g. ERK1/2, p38, and c-Jun NH2-terminal kinase, compared to the wild-type organism, naturally occurring V337M mutation of tau protein of mutants leads to age-dependent memory deficits Mus musculus ?
-
?
additional information naturally occurring V717I mutation of the amyloid precursor protein APP in a CT100 fragment of organisms with Alzheimer's disease leads to augmented age-dependent tau phosphorylation, followed by increased activation status of mitogen-activated protein kinase family members, e.g. ERK1/2, p38, and c-Jun NH2-terminal kinase, compared to the wild-type organism, naturally occurring V337M mutation of tau protein of patients suffering from Alzheimer's disease leads to age-dependent memory deficits Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
cyclin-dependent kinase 5
-
Mus musculus
cyclin-dependent kinase 5
-
Homo sapiens
glycogen synthase kinase-3alphabeta
-
Mus musculus
glycogen synthase kinase-3alphabeta
-
Homo sapiens
More see also EC 2.7.11.1 and EC 2.7.11.22 Mus musculus
More see also EC 2.7.11.1 and EC 2.7.11.22 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Mus musculus
ATP
-
Homo sapiens