Activating Compound | Comment | Organism | Structure |
---|---|---|---|
FRAT-2 | i.e. frequently rearranged in advanced T-cell lymphoma protein 2, activates phosphorylation of primed sites of tau protein about 8fold, no effect on unprimed site phosphorylation | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
transient co-expression of human tau long isoform, HA-tagged GSK3beta, and GST-tagged GFP-fusion FRAT-2 protein in HEK-293 cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
S9A | site-directed mutagenesis, mutant cannot be inhibited by phosphorylation at position 9 and is thus constitutively active | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | phosphorylation of GSK3beta at S9 inhibits the enzyme | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [tau-protein] | Homo sapiens | tau is primarily found in neurons, regulation of tau phosphorylation by GSK3beta via interaction with FRAT-1 and FRAT-2, i.e. frequently rearranged in advanced T-cell lymphoma proteins | ADP + O-phospho-[tau-protein] | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | phosphorylation of GSK3beta at S9 inhibits the enzyme | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
neuron | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [FRAT-2 protein] | i.e. frequently rearranged in advanced T-cell lymphoma protein 2, phosphorylation by GSK3beta | Homo sapiens | ADP + phosphorylated [FRAT-2 protein] | - |
? | |
ATP + [tau-protein] | tau is primarily found in neurons, regulation of tau phosphorylation by GSK3beta via interaction with FRAT-1 and FRAT-2, i.e. frequently rearranged in advanced T-cell lymphoma proteins | Homo sapiens | ADP + O-phospho-[tau-protein] | - |
? | |
ATP + [tau-protein] | phosphorylation of primed and unprimed sites by GSK3beta, wild-type and recombinant tau, recombinant GSK3beta S9A | Homo sapiens | ADP + O-phospho-[tau-protein] | - |
? | |
additional information | GSK3beta catalyzes tau phosphorylation in brain, but phosphorylation of glycogen synthase and other proteins, EC 2.7.11.1, in different tissues | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
glycogen synthase kinase 3 beta | - |
Homo sapiens |
GSK3beta | - |
Homo sapiens |
More | see also EC 2.7.11.1 | Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |