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Literature summary for 2.7.11.26 extracted from
- Physiology and pathology of tau protein kinases in relation to Alzheimer's disease (1997), J. Biochem., 121, 179-188.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | - |
Rattus norvegicus |
| medicine | TPKI/GSK-3beta plays a key role in the pathogenesis of Alzheimer disease, tau protein kinases I and II are candidate enzymes responsible for hyperphosphorylation of tau to induce formation of paired helical filaments | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| after cloning and cDNA analysis TPKI is found to be identical with glycogen synthase kinase 3beta, the catalytic subunit of TPKII is identical with cdc2-related kinase, PSSALRE/Cdk5 | Homo sapiens |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 23000 | - |
1 * 30000 + 1 * 23000, catalytic and regulatory subunit, SDS-PAGE | Homo sapiens |
| 30000 | - |
1 * 30000 + 1 * 23000, catalytic and regulatory subunit, SDS-PAGE | Homo sapiens |
| 45000 | - |
isoenzyme TPKI, SDS-PAGE | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + protein tau | Rattus norvegicus | - |
ADP + protein tau phosphate | - |
? |  |
| ATP + protein tau | Homo sapiens | prior phosphorylation of tau by isoenzyme TPKII strongly enhances the action of TPKI | ADP + protein tau phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
human | - |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Homo sapiens | - |
| brain | - |
Rattus norvegicus | - |
| embryo | - |
Rattus norvegicus | - |
| fetus | - |
Homo sapiens | - |
| fetus | - |
Rattus norvegicus | - |
| neuron | - |
Homo sapiens | - |
| neuron | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + histone H1 | isoenzyme TPKII | Homo sapiens | ADP + histone H1 phosphate | - |
? | |
| ATP + MAP2 | isoenzyme TPKII | Homo sapiens | ADP + MAP2 phosphate | - |
? | |
| ATP + protein tau | - |
Homo sapiens | ADP + protein tau phosphate | - |
? | |
| ATP + protein tau | - |
Rattus norvegicus | ADP + protein tau phosphate | - |
? | |
| ATP + protein tau | prior phosphorylation of tau by isoenzyme TPKII strongly enhances the action of TPKI | Homo sapiens | ADP + protein tau phosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| heterodimer | 1 * 30000 + 1 * 23000, catalytic and regulatory subunit, SDS-PAGE | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| TPK | - |
Homo sapiens |
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