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Literature summary for 2.7.11.24 extracted from

  • Kang, S.; Yang, F.; Li, L.; Chen, H.; Chen, S.; Zhang, J.
    The Arabidopsis transcription factor brassinosteroid insensitive1-ethyl methanesulfonate-suppressor1 is a direct substrate of mitogen-activated protein kinase6 and regulates immunity (2015), Plant Physiol., 167, 1076-1086.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.24

Activating Compound

Activating Compound Comment Organism Structure
additional information pathogen-associated molecular patterns (PAMPs) are recognized by plant pattern recognition receptors to activate PAMP-triggered immunity. PAMP perception enhances phosphorylation of BES1. Flagellin perception, e.g. of Flg22, enhances BES1 phosphorylation. Enzyme MKK5 phosphorylates and activates MPK6 Arabidopsis thaliana

Cloned(Commentary)

Cloned (Comment) Organism
recombinant expression of GST-tagged MPK6, coexpression of His-tagged BES1 and GST-tagged MPK6 in Nicotiana benthamiana, interaction analysis Arabidopsis thaliana

Localization

Localization Comment Organism GeneOntology No. Textmining
protoplast
-
 Arabidopsis thaliana
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Arabidopsis thaliana

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + BES1 Arabidopsis thaliana i.e. brassinosteroid insensitive1-ethyl methanesulfonate-suppressor1, an Arabidospis thaliana transcription factor. S286 and S137 residues are required for flg22-induced BES1 full phosphorylation in vivo, in which S286 plays a greater role than S137 ADP + phosphorylated BES1
-
 ?
ATP + BES1 Arabidopsis thaliana Col-0 i.e. brassinosteroid insensitive1-ethyl methanesulfonate-suppressor1, an Arabidospis thaliana transcription factor. S286 and S137 residues are required for flg22-induced BES1 full phosphorylation in vivo, in which S286 plays a greater role than S137 ADP + phosphorylated BES1
-
 ?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana Q39026
-
-
Arabidopsis thaliana Col-0 Q39026
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein enzyme MKK5 phosphorylates and activates MPK6 Arabidopsis thaliana

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + BES1 i.e. brassinosteroid insensitive1-ethyl methanesulfonate-suppressor1, an Arabidospis thaliana transcription factor. S286 and S137 residues are required for flg22-induced BES1 full phosphorylation in vivo, in which S286 plays a greater role than S137 Arabidopsis thaliana ADP + phosphorylated BES1
-
 ?
ATP + BES1 i.e. brassinosteroid insensitive1-ethyl methanesulfonate-suppressor1, an Arabidospis thaliana transcription factor Arabidopsis thaliana ADP + phosphorylated BES1
-
 ?
ATP + BES1 i.e. brassinosteroid insensitive1-ethyl methanesulfonate-suppressor1, an Arabidospis thaliana transcription factor. S286 and S137 residues are required for flg22-induced BES1 full phosphorylation in vivo, in which S286 plays a greater role than S137 Arabidopsis thaliana Col-0 ADP + phosphorylated BES1
-
 ?
ATP + BES1 i.e. brassinosteroid insensitive1-ethyl methanesulfonate-suppressor1, an Arabidospis thaliana transcription factor Arabidopsis thaliana Col-0 ADP + phosphorylated BES1
-
 ?

Synonyms

Synonyms Comment Organism
MAPK
-
 Arabidopsis thaliana
mitogen-activated protein kinase6
-
 Arabidopsis thaliana
MPK6
-
 Arabidopsis thaliana

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Arabidopsis thaliana

General Information

General Information Comment Organism
metabolism pathogen-associated molecular patterns (PAMPs) are recognized by plant pattern recognition receptors to activate PAMP-triggered immunity. PAMP perception enhances phosphorylation of BES1. BES1 is a unique direct substrate of MPK6 in PAMP-triggered immunity signaling. MAPK-mediated BES1 phosphorylation is another BES1 modulation mechanism in plant cell signaling, in addition to GSK3-like kinase-mediated BES1 phosphorylation and F box protein-mediated BES1 degradation. BES1 phosphorylation induced by flg22 occurs downstream of MAPK activation. MKK5K99M acts as a dominant negative mutant that partially blocks MAPK activation and downstream PTI signaling Arabidopsis thaliana
physiological function brassinosteroid insensitive1-ethyl methanesulfonate-suppressor1, BES1, is phosphorylted by Arabidospis thaliana MPK6. MAPK-mediated phosphorylation alters BES1 subcellular accumulation in PAMP-triggered immunity Arabidopsis thaliana