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Literature summary for 2.7.11.24 extracted from

  • Sakurai, T.; Yoshiga, D.; Ariyoshi, W.; Okinaga, T.; Kiyomiya, H.; Furuta, J.; Yoshioka, I.; Tominaga, K.; Nishihara, T.
    Essential role of mitogen-activated protein kinases in IL-17A-induced MMP-3 expression in human synovial sarcoma cells (2016), BMC Res. Notes, 9, 68.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
SB239063
-
Homo sapiens
SP600125
-
Homo sapiens
U0126
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Homo sapiens P27361
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HS-SY-II cell
-
Homo sapiens
-
synovial sarcoma cell
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
c-Jun NH2-terminal kinase
-
Homo sapiens
ERK1
-
Homo sapiens
ERK2
-
Homo sapiens
extracellular signal-regulated kinase 1
-
Homo sapiens
extracellular signal-regulated kinase 2
-
Homo sapiens
JNK
-
Homo sapiens
MAPK
-
Homo sapiens
MAPK3
-
Homo sapiens
p38 MAPK
-
Homo sapiens

General Information

General Information Comment Organism
malfunction pre-treatment of human synovial sarcoma cells with inhibitors of ERK1/2, p38 MAPK, and JNK attenuates the IL-17A-induced phosphorylation of activator protein-1 (AP-1) subunits and the expression of MMP-3 mRNA Homo sapiens
physiological function essential role of mitogen-activated protein kinases in IL-17A-induced matrix metalloproteinase MMP-3 expression in human synovial sarcoma cells, overview Homo sapiens
physiological function essential role of mitogen-activated protein kinases in IL-17A-induced matrix metalloproteinase MMP-3 expression in human synovial sarcoma cells, overview. IL-17A induces MMP-1 and MMP-9 via ERK1/2 and p38 MAPK-dependent activation of the transcriptional factors activator protein-1 (AP-1) and nuclear factor-kappa B (NF-kappaB) Homo sapiens