Inhibitors | Comment | Organism | Structure |
---|---|---|---|
SB239063 | - |
Homo sapiens | |
SP600125 | - |
Homo sapiens | |
U0126 | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Homo sapiens | P27361 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HS-SY-II cell | - |
Homo sapiens | - |
synovial sarcoma cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
c-Jun NH2-terminal kinase | - |
Homo sapiens |
ERK1 | - |
Homo sapiens |
ERK2 | - |
Homo sapiens |
extracellular signal-regulated kinase 1 | - |
Homo sapiens |
extracellular signal-regulated kinase 2 | - |
Homo sapiens |
JNK | - |
Homo sapiens |
MAPK | - |
Homo sapiens |
MAPK3 | - |
Homo sapiens |
p38 MAPK | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | pre-treatment of human synovial sarcoma cells with inhibitors of ERK1/2, p38 MAPK, and JNK attenuates the IL-17A-induced phosphorylation of activator protein-1 (AP-1) subunits and the expression of MMP-3 mRNA | Homo sapiens |
physiological function | essential role of mitogen-activated protein kinases in IL-17A-induced matrix metalloproteinase MMP-3 expression in human synovial sarcoma cells, overview | Homo sapiens |
physiological function | essential role of mitogen-activated protein kinases in IL-17A-induced matrix metalloproteinase MMP-3 expression in human synovial sarcoma cells, overview. IL-17A induces MMP-1 and MMP-9 via ERK1/2 and p38 MAPK-dependent activation of the transcriptional factors activator protein-1 (AP-1) and nuclear factor-kappa B (NF-kappaB) | Homo sapiens |