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Literature summary for 2.7.11.24 extracted from

  • Stamboulian, S.; Choi, J.S.; Ahn, H.S.; Chang, Y.W.; Tyrrell, L.; Black, J.A.; Waxman, S.G.; Dib-Hajj, S.D.
    ERK1/2 mitogen-activated protein kinase phosphorylates sodium channel Na(v)1.7 and alters its gating properties (2010), J. Neurosci., 30, 1637-1647.
    View publication on PubMedView publication on EuropePMC
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Activating Compound

Activating Compound Comment Organism Structure
glial cell line-derived neurotrophic factor GDNF Rattus norvegicus
neurotrophic growth factor NGF Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
1,4-diamino-2,3-dicyano-1,4-bis(o-aminophenylmercapto)butadiene U0126 Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
40000
-
 determined by SDS-PAGE and Western-blot analysis Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + a protein Rattus norvegicus
-
 ADP + a phosphoprotein
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 Sprague Dawley rat
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein
-
 Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
ganglion dorsal root ganglion Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + a protein
-
 Rattus norvegicus ADP + a phosphoprotein
-
 ?
ATP + sodium channel Na(v)1.6
-
 Rattus norvegicus ADP + phosphorylated sodium channel Na(v)1.6
-
 ?
ATP + sodium channel Na(v)1.7
-
 Rattus norvegicus ADP + phosphorylated sodium channel Na(v)1.7
-
 ?
ATP + sodium channel Na(v)1.8
-
 Rattus norvegicus ADP + phosphorylated sodium channel Na(v)1.8
-
 ?

Synonyms

Synonyms Comment Organism
ERK1/2 mitogen-activated protein kinase
-
 Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 kinase assay Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Rattus norvegicus

General Information

General Information Comment Organism
physiological function pERK1/2 appears to specifically modulate gating properties of Na(v)1.7, an effect that may contribute to the role of this channel in dorsal root ganglion neuron excitability Rattus norvegicus